ArticleConservation physiology2018
Urbanization, environment and pharmaceuticals: advancing comparative physiology, pharmacology and toxicology.
Article in Conservation physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 44 citations in OpenAlex.
- Towards Precision Ecotoxicology: Leveraging Evolutionary Conservation of Pharmaceutical and Personal Care Product Targets to Understand Adverse Outcomes Across Species and Life Stages.Environmental toxicology and chemistry · 2024Review
- A Novel Photopharmacological Tool: Dual-Step Luminescence for Biological Tissue Penetration of Light and the Selective Activation of Photodrugs.International journal of molecular sciences · 2023Article
- Chemical Degradation of Intravenous Chemotherapy Agents and Opioids by a Novel Instrument.Hospital pharmacy · 2021Article
- Comparative acute toxicity of benzophenone derivatives and bisphenol analogues in the Asian clam Corbicula fluminea.Ecotoxicology (London, England) · 2021Article
- Toward Sustainable Environmental Quality: Priority Research Questions for Asia.Environmental toxicology and chemistry · 2020Review
- Toxicology Advances for 21One earth (Cambridge, Mass.) · 2020Article
- Reframing conservation physiology to be more inclusive, integrative, relevant and forward-looking: reflections and a horizon scan.Conservation physiology · 2020Article
- Towards Sustainable Environmental Quality: Priority Research Questions for the Australasian Region of Oceania.Integrated environmental assessment and management · 2019Article
- Toward Sustainable Environmental Quality: Priority Research Questions for North America.Environmental toxicology and chemistry · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharmaceuticals are routinely reported in the environment, which indicates an increasingly urban water cycle and highlights a global megatrend. Physicochemical properties and intrinsic biological activity of medicines routinely differ from conventional organic contaminants; thus, diverging applicability domains often challenge environmental chemistry and toxicology computational tools and biological assays originally developed to address historical chemical stressors. Because pharmacology and toxicology information is more readily available for these contaminants of emerging concern than other chemicals in the environment, and many drug targets are conserved across species, leveraging mammalian drug discovery, safety testing and clinical pharmacology information appears useful to define environmental risks and to design less hazardous industrial chemicals. Research is needed to advance biological read across, which promises to reduce uncertainties during chemical assessment aimed at protecting public health and the environment. Whereas such comparative information has been critical to advance an understanding of pharmaceutical hazards and risks in urban ecosystems, studies of medicines with fish and other ecotoxicological models are reciprocally benefiting basic and translational efforts, advancing comparative mechanistic toxicology, and providing robust comparative bridges for integrating conservation and toxicology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.