ArticleFrontiers in human neuroscience2018
Whole-Brain Network Connectivity Underlying the Human Speech Articulation as Emerged Integrating Direct Electric Stimulation, Resting State fMRI and Tractography.
Article in Frontiers in human neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- A probabilistic map of motor and cognitive functions: a meta-analysis of 4325 stimulation sites.Brain structure & function · 2025Pooled it
- Intraoperative mapping of the right hemisphere: a systematic review of protocols that evaluate cognitive and social cognitive functions.Frontiers in psychology · 2024Pooled it
- Surgical management of Glioma Grade 4: technical update from the neuro-oncology section of the Italian Society of Neurosurgery (SINch®): a systematic review.Journal of neuro-oncology · 2023Pooled it
- Immediate and long-term effects of speech treatment targets and intensive dosage on Parkinson's disease dysphonia and the speech motor network: Randomized controlled trial.Human brain mapping · 2022Trial
- The anatomical and radiologic relationship of the superior longitudinal system with the middle cerebral artery branches.Acta neurochirurgica · 2026Article
- Causal parametric language mapping with electrical stimulation during awake neurosurgery.Science advances · 2026Article
- Integrating direct electrical stimulation with brain connectivity predicts lesion-induced language impairment and recovery.Communications medicine · 2025Article
- Anatomical insights into the superior longitudinal system from integrative in- vivo and ex-vivo mapping.Communications biology · 2025Article
- A speech fluency brain network derived from gliomas.Brain communications · 2024Article
- Review
- Baseline neurocognitive dysfunction is ubiquitous in intrinsic brain tumors- results from a large Indian cohort of patients and analysis of factors associated with domain-specific dysfunction.World neurosurgery: X · 2023Article
- Personal space regulation is affected by unilateral temporal lesions beyond the amygdala.Cerebral cortex communications · 2022Article
- Hodology of the superior longitudinal system of the human brain: a historical perspective, the current controversies, and a proposal.Brain structure & function · 2021Review
- Recovery of Apraxia of Speech and Aphasia in Patients With Hand Motor Impairment After Stroke.Frontiers in neurology · 2021Article
- The Role of the Dorsolateral Prefrontal Cortex for Speech and Language Processing.Frontiers in human neuroscience · 2021Article
- A unified neurocomputational bilateral model of spoken language production in healthy participants and recovery in poststroke aphasia.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Effects of supra-total resection in neurocognitive and oncological outcome of high-grade gliomas comparing asleep and awake surgery.Journal of neuro-oncology · 2020Article
- A normalized dataset of 1821 cortical and subcortical functional responses collected during direct electrical stimulation in patients undergoing awake brain surgery.Data in brief · 2020Article
- Mapping critical cortical hubs and white matter pathways by direct electrical stimulation: an original functional atlas of the human brain.NeuroImage · 2020Article
- Editorial: Organization of the White Matter Anatomy in the Human Brain.Frontiers in neuroanatomy · 2019Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Production of fluent speech in humans is based on a precise and coordinated articulation of sounds. A speech articulation network (SAN) has been observed in multiple brain studies typically using either neuroimaging or direct electrical stimulation (DES), thus giving limited knowledge about the whole brain structural and functional organization of this network. In this study, seven right-handed patients underwent awake surgery resection of low-grade gliomas (4) and cavernous angiomas. We combined pre-surgical resting state fMRI (rs-fMRI) and diffusion MRI together with speech arrest sites obtained intra-operatively with DES to address the following goals: (i) determine the cortical areas contributing to the intrinsic functional SAN using the speech arrest sites as functional seeds for rs-fMRI; (ii) evaluate the relative contribution of gray matter terminations from the two major language dorsal stream bundles, the superior longitudinal fasciculus (SLF III) and the arcuate fasciculus (AF); and (iii) evaluate the possible pre-surgical prediction of SAN with rs-fMRI. In all these right-handed patients the intrinsic functional SAN included frontal, inferior parietal, temporal, and insular regions symmetrically and bilaterally distributed across the two hemispheres regardless of the side (four right) of speech arrest evocation. The SLF III provided a much higher density of terminations in the cortical regions of SAN in respect to AF. Pre-surgical rs-fMRI data demonstrated moderate ability to predict the SAN. The set of functional and structural data provided in this multimodal study characterized, at a whole-brain level, a distributed and bi-hemispherical network subserving speech articulation.
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