Evidence map›Paper›PMID 30364222›Full record

ReviewFrontiers in immunology2018

Molecular Mechanisms Directing Migration and Retention of Natural Killer Cells in Human Tissues.

Roberta Castriconi, Paolo Carrega, Alessandra Dondero, Francesca Bellora, Beatrice Casu, Stefano Regis, Guido Ferlazzo, Cristina Bottino

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 121 citations in OpenAlex.

  1. Review
  2. Article
  3. Chemokines in Pregnancy.Biomolecules · 2025
    Review
  4. Restoring NK Cell Cytotoxicity Post-Cryopreservation via Synthetic Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. The role of CD56Journal of neuroinflammation · 2024
    Review
  11. Article
  12. Review
  13. Human NK cells and cancer.Oncoimmunology · 2024
    Review
  14. Natural killer cells in the lung: potential role in asthma and virus-induced exacerbation?European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  15. Article
  16. Review
  17. Article
  18. NK Cells in Cancer: Mechanisms of Dysfunction and Therapeutic Potential.International journal of molecular sciences · 2023
    Review
  19. Pathogens (Basel, Switzerland) · 2023
    Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Roberta CastriconiDipartimento di Medicina Sperimentale, University of Genova, Genova, Italy.
Paolo CarregaDipartimento di Patologia Umana, University of Messina, Messina, Italy.
Alessandra DonderoDipartimento di Medicina Sperimentale, University of Genova, Genova, Italy.
Francesca BelloraDipartimento di Medicina Sperimentale, University of Genova, Genova, Italy.
Beatrice CasuDipartimento di Medicina Sperimentale, University of Genova, Genova, Italy.
Stefano RegisIstituto di ricovero e cura a carattere scientifico (IRCCS) Giannina Gaslini, Genova, Italy.
Guido FerlazzoDipartimento di Patologia Umana, University of Messina, Messina, Italy.
Cristina BottinoDipartimento di Medicina Sperimentale, University of Genova, Genova, Italy.
University of Genoa · ITUniversity of Messina · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A large body of data shows that Natural Killer (NK) cells are immune effectors exerting a potent cytolytic activity against tumors and virus infected cells. The discovery and characterization of several inhibitory and activating receptors unveiled most of the mechanisms allowing NK cells to spare healthy cells while selectively attacking abnormal tissues. Nevertheless, the mechanisms ruling NK cell subset recirculation among the different compartments of human body have only lately started to be investigated. This is particularly true for pathological settings such as tumors or infected tissues but also for para-physiological condition like pregnant human uterine mucosa. It is becoming evident that the microenvironment associated to a particular clinical condition can deeply influence the migratory capabilities of NK cells. In this review we describe the main mechanisms and stimuli known to regulate the expression of chemokine receptors and other molecules involved in NK cell homing to either normal or pathological/inflamed tissues, including tumors or organs such as lung and liver. We will also discuss the role played by the chemokine/chemokine receptor axes in the orchestration of physiological events such as NK cell differentiation, lymphoid organ retention/egress and recruitment to decidua during pregnancy.

Indexed as

AnimalsCell MovementCytokinesCytotoxicity, ImmunologicFemaleHumansInflammationKiller Cells, NaturalNeoplasmsOrgan SpecificityPregnancyCytokineschemokines and chemokine receptorsmigration and residencynatural killer cellspregnancytumor and inflammation

Identifiers

PMID30364222
PMCPMC6193061
OpenAlexW2897940630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.