Evidence map›Paper›PMID 30364182›Full record

ArticleFrontiers in immunology2018

Accumulation of Multipotent Hematopoietic Progenitors in Peripheral Lymphoid Organs of Mice Over-expressing Interleukin-7 and Flt3-Ligand.

Fabian Klein, Lilly von Muenchow, Giuseppina Capoferri, Stefan Heiler, Llucia Alberti-Servera, Hannie Rolink, Corinne Engdahl, Michael Rolink, Mladen Mitrovic, Grozdan Cvijetic and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Long-Acting Recombinant Human Interleukin-7, NT-I7, Increases Cytotoxic CD8 T Cells and Enhances Survival in Mouse Glioma Models.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Fabian KleinDepartment of Biomedicine, Developmental and Molecular Immunology, University of Basel, Basel, Switzerland.
Lilly von MuenchowDepartment of Biomedicine, Developmental and Molecular Immunology, University of Basel, Basel, Switzerland.
Giuseppina CapoferriDepartment of Biomedicine, Developmental and Molecular Immunology, University of Basel, Basel, Switzerland.
Stefan HeilerDepartment of Biomedicine, Developmental and Molecular Immunology, University of Basel, Basel, Switzerland.
Llucia Alberti-ServeraDepartment of Biomedicine, Developmental and Molecular Immunology, University of Basel, Basel, Switzerland.
Hannie RolinkDepartment of Biomedicine, Developmental and Molecular Immunology, University of Basel, Basel, Switzerland.
Corinne EngdahlDepartment of Biomedicine, Developmental and Molecular Immunology, University of Basel, Basel, Switzerland.
Michael RolinkDepartment of Biomedicine, Developmental and Molecular Immunology, University of Basel, Basel, Switzerland.
Mladen MitrovicDepartment of Biomedicine, Developmental and Molecular Immunology, University of Basel, Basel, Switzerland.
Grozdan CvijeticDepartment of Biomedicine, Developmental and Molecular Immunology, University of Basel, Basel, Switzerland.
Jan AnderssonDepartment of Biomedicine, Developmental and Molecular Immunology, University of Basel, Basel, Switzerland.
Rhodri CeredigDiscipline of Physiology, College of Medicine & Nursing Health Science, National University of Ireland, Galway, Ireland.
Panagiotis TsapogasDepartment of Biomedicine, Developmental and Molecular Immunology, University of Basel, Basel, Switzerland.
Antonius RolinkDepartment of Biomedicine, Developmental and Molecular Immunology, University of Basel, Basel, Switzerland.
University of Basel · CHOllscoil na Gaillimhe – University of Galway · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin-7 (IL-7) and Flt3-ligand (FL) are two cytokines important for the generation of B cells, as manifested by the impaired B cell development in mice deficient for either cytokine or their respective receptors and by the complete block in B cell differentiation in the absence of both cytokines. IL-7 is an important survival and proliferation factor for B cell progenitors, whereas FL acts on several early developmental stages, prior to B cell commitment. We have generated mice constitutively over-expressing both IL-7 and FL. These double transgenic mice develop splenomegaly and lymphadenopathy characterized by tremendously enlarged lymph nodes even in young animals. Lymphoid, myeloid and dendritic cell numbers are increased compared to mice over-expressing either of the two cytokines alone and the effect on their expansion is synergistic, rather than additive. B cell progenitors, early progenitors with myeloid and lymphoid potential (EPLM), common lymphoid progenitors (CLP) and lineage

Indexed as

AnimalsCell ProliferationCell SurvivalGene ExpressionHematopoietic Stem CellsInterleukin-7Lymphoid Progenitor CellsMembrane ProteinsMiceMice, Inbred C57BLMice, Inbred NODMice, KnockoutMice, SCIDMice, TransgenicMultipotent Stem Cellsflt3 ligand proteinInterleukin-7Membrane ProteinsB cell developmentcytokinesFlt3-ligandhematopoiesisIL-7

Identifiers

PMID30364182
PMCPMC6191501
OpenAlexW2897973524

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.