Evidence map›Paper›PMID 30364113›Full record

ArticleFrontiers in physiology2018

Comparative Expression of Renin-Angiotensin Pathway Proteins in Visceral Versus Subcutaneous Fat.

Yuebo Zhang, Kiran R Somers, Christiane Becari, Katarzyna Polonis, Michaela A Pfeifer, Alina M Allen, Todd A Kellogg, Naima Covassin, Prachi Singh

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
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  7. Article
  8. Article
  9. Angiotensin II Inhibits Insulin Receptor Signaling in Adipose Cells.International journal of molecular sciences · 2022
    Article
  10. Review
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  16. Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19: a large retrospective study from the Bronx, New York.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yuebo ZhangDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.
Kiran R SomersDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.
Christiane BecariDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.
Katarzyna PolonisDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.
Michaela A PfeiferDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.
Alina M AllenDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States.
Todd A KelloggDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.
Naima CovassinDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.
Prachi SinghDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States.
Mayo Clinic in Arizona · US

Funding

APS Short-Term Research Education Program to Increase Diversity in Health-RelatedR25HL115473 · NHLBI · AMERICAN PHYSIOLOGICAL SOCIETY · PI BRUTHERS, CHERYL BROOKE, MATYAS, MARSHA LAKES · 2012 to 2017
$853k
Noninvasive detection of NASH by magnetic resonance elastography (MRE)K23DK115594 · NIDDK · MAYO CLINIC ROCHESTER · PI ALLEN, ALINA M · 2018 to 2022
$846k
NHLBI NIH HHS R25 HL115473NIDDK NIH HHS K23 DK115594
6 · The paper itself

Abstract

Body fat distribution contributes to obesity-related metabolic and cardiovascular disorders. Visceral fat is more detrimental than subcutaneous fat. However, the mechanisms underlying visceral fat-mediated cardiometabolic dysregulation are not completely understood. Localized increases in expression of the renin angiotensin system (RAS) in adipose tissue (AT) may be implicated. We therefore investigated mRNA and protein expression of RAS components in visceral versus subcutaneous AT using paired samples from individuals undergoing surgery (

Indexed as

angiotensinchymasefat distributionMas receptorobesityrenin-angiotensin systemvisceral fat

Identifiers

PMID30364113
PMCPMC6191467
OpenAlexW2895901425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.