Evidence map›Paper›PMID 30364100›Full record

ReviewFrontiers in neural circuits2018

Shaping Diversity Into the Brain's Form and Function.

Lauren N Miterko, Elizabeth P Lackey, Detlef H Heck, Roy V Sillitoe

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neural circuits, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

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  14. Functional Outcomes of Cerebellar Malformations.Frontiers in cellular neuroscience · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Lauren N MiterkoDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, United States.
Elizabeth P LackeyDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, United States.
Detlef H HeckDepartment of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, United States.
Roy V SillitoeDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, United States.
Baylor College of Medicine · USNeurological Research Institute · USUniversity of Tennessee Health Science Center · US

Funding

Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
Neuronal mechanisms of cerebellar cognitive functionR01MH112143 · NIMH · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI HECK, DETLEF H · 2018 to 2022
$2.3M
CEREBELLAR FUNCTION IN TREMORR01NS100874 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2017 to 2021
$1.9M
SYNAPTIC ORIGINS OF CEREBELLAR DISEASER01NS089664 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2014 to 2018
$1.7M
NICHD NIH HHS U54 HD083092NIMH NIH HHS R01 MH112143NINDS NIH HHS R01 NS089664NINDS NIH HHS R01 NS100874
6 · The paper itself

Abstract

The brain contains a large diversity of unique cell types that use specific genetic programs to control development and instruct the intricate wiring of sensory, motor, and cognitive brain regions. In addition to their cellular diversity and specialized connectivity maps, each region's dedicated function is also expressed in their characteristic gross external morphologies. The folds on the surface of the cerebral cortex and cerebellum are classic examples. But, to what extent does structure relate to function and at what spatial scale? We discuss the mechanisms that sculpt functional brain maps and external morphologies. We also contrast the cryptic structural defects in conditions such as autism spectrum disorders to the overt microcephaly after Zika infections, taking into consideration that both diseases disrupt proper cognitive development. The data indicate that dynamic processes shape all brain areas to fit into jigsaw-like patterns. The patterns in each region reflect circuit connectivity, which ultimately supports local signal processing and accomplishes multi-areal integration of information processing to optimize brain functions.

Indexed as

Brain MappingAction PotentialsAnimalsBrainHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNerve Netconnectivityfoldingglialayeringneuronpatterningtopography

Identifiers

PMID30364100
PMCPMC6191489
OpenAlexW2896790213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.