ReviewF1000Research2018
Recent advances in understanding and managing chronic constipation.
Review in F1000Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Probiotics in Alleviating Constipation: Mechanisms, Strain Screening, and Applications.Biology · 2026Review
- Wheat Peptides Promote Recovery of the Enteric Nervous System via mAChR Activation to Relieve Constipation in Mice.ACS omega · 2026Article
- Early Therapeutic Response Predicts Outcome in Chronic Constipation: A Multicenter Prospective Observational Study.Gastroenterology research · 2026Article
- Development and validation of a nomogram for predicting postoperative new-onset constipation in elderly patients undergoing hip fracture surgery.Scientific reports · 2025Article
- A Low FODMAP Diet Supplemented with L-Tryptophan Reduces the Symptoms of Functional Constipation in Elderly Patients.Nutrients · 2024Article
- Tryptophan Metabolism in Postmenopausal Women with Functional Constipation.International journal of molecular sciences · 2023Article
- Luteolin ameliorates loperamide-induced functional constipation in mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Article
- Prokinetic and Laxative Effects ofMolecules (Basel, Switzerland) · 2022Article
- Prevention and Treatment of Side Effects of Immunotherapy for Bladder Cancer.Frontiers in oncology · 2022Review
- Review article: diagnosis, management and patient perspectives of the spectrum of constipation disorders.Alimentary pharmacology & therapeutics · 2021Review
- Deciphering the correlations between aging and constipation by metabolomics and network pharmacology.Aging · 2021Article
- Roles of Gut Microbiota and Metabolites in Pathogenesis of Functional Constipation.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Efficacy and Safety of Maxing Xianchang Su in the Treatment of Functional Constipation: A Randomized Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- The effect of sodium carboxymethyl starch with high degree of substitution on defecation.PloS one · 2021Article
- Clinical Evaluation of a Patient With Symptoms of Colonic or Anorectal Motility Disorders.Journal of neurogastroenterology and motility · 2020Review
- Is Constipation Associated with Worse Functioning in Adult Women? A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2020Article
- Daikenchuto, a traditional Japanese herbal medicine, promotes colonic transit by inducing a propulsive movement pattern.Neurogastroenterology and motility · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Constipation, a condition characterized by heterogeneous symptoms, is common in Western society. It is associated with reduced physical health, mental health, and social functioning. Because constipation is rarely due to a life-threatening disease (for example, colon cancer), current guidelines recommend empiric therapy. Limited surveys suggest that fewer than half of treated individuals are satisfied with treatment, perhaps because the efficacy of drugs is limited, they are associated with undesirable side effects, or they may not target the underlying pathophysiology. For example, although a substantial proportion of constipated patients have a defecatory disorder that is more appropriately treated with pelvic floor biofeedback therapy than with laxatives, virtually no pharmacological trials formally assessed for anorectal dysfunction. Recent advances in investigational tools have improved our understanding of the physiology and pathophysiology of colonic and defecatory functions. In particular, colonic and anorectal high-resolution manometry are now available. High-resolution anorectal manometry, which is increasingly used in clinical practice, at least in the United States, provides a refined assessment of anorectal pressures and may uncover structural abnormalities. Advances in our understanding of colonic molecular physiology have led to the development of new therapeutic agents (such as secretagogues, pro-kinetics, inhibitors of bile acid transporters and ion exchangers). However, because clinical trials compare these newer agents with placebo, their efficacy relative to traditional laxatives is unknown. This article reviews these physiologic, diagnostic, and therapeutic advances and focuses particularly on newer therapeutic agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.