ArticleEvidence-based complementary and alternative medicine : eCAM2018
A New Model of Diarrhea with Spleen-Kidney Yang Deficiency Syndrome.
Article in Evidence-based complementary and alternative medicine : eCAM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Integrating Metabolomics and Transcriptomics Reveals the Multi-Target Mechanisms of FermentedNutrients · 2026Article
- Prevalence of Traditional East Asian Medicine Patterns among Older Adults with Frailty: a systematic review of observational studies.Journal of pharmacopuncture · 2026Review
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- Body constitutions of traditional Chinese medicine caused a significant effect on irritable bowel syndrome.Journal of the Chinese Medical Association : JCMA · 2024Article
- Effect of xylo-oligosaccharides on intestinal bacterial diversity in mice with spleen deficiency constipation.Frontiers in microbiology · 2024Article
- Efficacy of stimulating Mingmen (GV4) and Guanyuan (CV4) on kidney deficiency in rat model: laser irradiation traditional moxibustion.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Article
- Polysaccharides from Pseudostellaria heterophylla modulate gut microbiota and alleviate syndrome of spleen deficiency in rats.Scientific reports · 2022Article
- Traditional Chinese Medicine Body Constitutions as Predictors for Depression: A Systematic Review and Meta-Analysis.Behavioral sciences (Basel, Switzerland) · 2022Review
- Effects of a Chinese herbal extract on the intestinal tract and aquaporin in Adriamycin-induced nephropathy.Bioengineered · 2022Article
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- Effects of 10.6-μm laser moxibustion and electroacupuncture at ST36 in a 5-Fu-induced diarrhea rat model.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Shenling Baizhu Powder () Ameliorates Pi (Spleen)-Deficiency-Induced Functional Diarrhea in Rats.Chinese journal of integrative medicine · 2021Article
- Role of tryptophan-metabolizing microbiota in mice diarrhea caused by Folium sennae extracts.BMC microbiology · 2020Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to examine a new method to create a rat model of diarrhea with spleen-kidney yang deficiency syndrome.
methodsA senna leaf (Folium sennae) decoction was made in 3 concentrations of 1.0, 0.5, and 0.25 g/mL. Rats were randomly divided into 4 groups: the control (C)-, high (H)-, middle (M)-, and low (L)- dose groups. The groups received saline, 1.0, 0.5, or 0.25 g/mL senna leaf decoction, respectively, for 4 weeks. Body weight monitoring, food consumption, water intake, defecation frequency, stool Bristol score, weight-loaded forced swimming test, forelimb grip strength test, D-xylose absorption test, serum cortisone, adrenocorticotropic hormone (ACTH), 24 h urine 17-hydroxycorticosteroid (17-OHCS), and histopathological detection were conducted to assess the success of the senna leaf decoction-induced model.
resultsThis study showed that the senna leaf decoction could induce diarrhea and dose-dependently slow body weight growth, reduce food consumption, and increase water intake, stool Bristol score, and defecation frequency. Statistical differences were found between groups H and M in rectal temperature, weight-loaded forced swimming time, forelimb grip strength, and serum cortisone. The D-xylose absorption test also showed dysfunction of intestinal absorption in groups H and M. The serum cortisone and 24 h urine 17-OHCS were significantly reduced in group H.
conclusionsGastric gavage of 10 mL/kg of body weight of a high concentration of a senna leaf decoction (1.0 g/mL) for 4 weeks was used to create a rat model of diarrhea with spleen-kidney yang deficiency syndrome.
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Registered trials
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