ArticleBioMed research international2018
Comparison of Synovial Fluid and Serum Procalcitonin for Diagnosis of Periprosthetic Joint Infection: A Pilot Study in 32 Patients.
Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Reliable Diagnostic Tests and Thresholds for Preoperative Diagnosis of Non-Inflammatory Arthritis Periprosthetic Joint Infection: A Meta-analysis and Systematic Review.Orthopaedic surgery · 2022Pooled it
- Periprosthetic joint infection after arthroplasty: advances and future prospects.Journal of orthopaedic surgery and research · 2025Review
- What are the diagnoses attributed to persistent hip pain after hip arthroplasty? A systematic review.Journal of clinical orthopaedics and trauma · 2025Review
- Comparison of the Diagnostic Performance of Culture, Histopathology, and mNGS for Periprosthetic Joint Infection Using Periprosthetic Tissue Samples: A Prospective Clinical Study.Infection and drug resistance · 2025Article
- Construction and evaluation of a combined diagnostic model for chronic periprosthetic joint infection based on serological tests.Journal of orthopaedic surgery and research · 2024Article
- Diagnostic value of procalcitonin in patients with periprosthetic joint infection: a diagnostic meta-analysis.Frontiers in surgery · 2024Review
- Serum procalcitonin has no significance in the diagnosis of periprosthesis joint infection before total hip and knee replacement.Frontiers in surgery · 2023Article
- Role of Biomarkers in Periprosthetic Joint Infections.Diagnostics (Basel, Switzerland) · 2022Review
- Role of serum and synovial procalcitonin in differentiating septic from non-septic arthritis- a prospective study.Journal of clinical orthopaedics and trauma · 2022Article
- Current Clinical Methods for Detection of Peri-Prosthetic Joint Infection.Surgical infections · 2020Review
- Is Procalcitonin (PCT) a reliable biomarker for preoperative diagnosing of low grade periprosthetic joint infection? A prospective study.BMC musculoskeletal disorders · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriprosthetic joint infection (PJI) remains challenging since a "gold standard" for diagnosis has not yet been established. This study aimed to evaluate the accuracy of synovial fluid procalcitonin (SF-PCT) and serum procalcitonin as a diagnostic biomarker for PJI and to compare its accuracy against standard methods.
methodsA prospective cohort study was conducted during 2015-2017 in 32 patients with painful hip or knee arthroplasty who have underwent revision surgery. Relevant clinical and laboratory data were collected. PJI was diagnosed based on the 2013 international consensus criteria. Preoperative blood sample and intraoperatively acquired joint fluid were taken for PCT measurement with a standard assay. Diagnostic accuracy was analyzed by the receiver-operating characteristic curve and the area under the curve (AUC).
resultsTwenty patients (62.5%) were classified as the PJI group, and 12 (37.5%) were classified as the aseptic loosening group. The median age was 68 years (range 38-87 years). The median values of SF-PCT and serum PCT in the PJI group were both significantly higher than those in the aseptic loosening group: the median serum PCT levels (interquartile range: IQR) were 0.33 ng/mL (0.08-2.79 ng/mL) in the PJI group compared with 0.04 ng/mL (0.03-0.06 ng/mL), and the median SF-PCT levels (IQR) were 0.16 ng/mL (0.12-0.26 ng/mL) in PJI group compared with 0.00 (0.00-0.00 ng/mL) (
conclusionSF-PCT appears to be a reliable test and could be useful as an alternative indicator or in combination with standard methods for diagnosing PJI.
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