ArticleAnnals of translational medicine2018
Administration routes affect thrombolytic effect of catheter-directed thrombolysis with pro-urokinase in treating deep vein thrombosis.
Article in Annals of translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Efficacy and Safety of Low-Dose Prolonged Infusion Thrombolysis With rt-PA for Acute Intermediate-High Risk Pulmonary Embolism.Pulmonary circulation · 2026Article
- The plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis.Scientific reports · 2021Article
- Early diagnosis and precision treatment of right ovarian vein and inferior vena cava thrombosis following caesarean section: A case report.Experimental and therapeutic medicine · 2020Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeep venous thrombosis (DVT) is a common disorder with a significant mortality rate. Catheter-directed thrombolysis (CDT) is a preferred treatment for DVT patients. The aim of this study is to evaluate the thrombolytic effect of CDT with pro-urokinase (pro-UK) in different administration routes.
methodsAn inferior vena cava (IVC) model was induced in 36 New Zealand white rabbits by catheter injury and placement of IVC filter. The animals were divided into 6 groups with 6 rabbits in each group: group A: systemic thrombolysis with intravenous injection; group B: CDT with pump infusion; group C: CDT with pulse injection; group D: CDT with combination of pump infusion and pulse injection; group E: catheter-directed aspiration thrombectomy; group F: mechanical thrombectomy. The thrombolytic effects were evaluated by color Doppler ultrasound and blood measurement of D-dimer and fibrinogen.
resultsThe minimum effective concentration of pro-UK solution was identified. Two groups (group A and B) did not achieve successful thrombolysis. Among all catheter-directed administration groups, the rabbit groups that received pro-UK therapy through catheter-directed thrombolytic pump infusion combined with pulse injection (group D) showed the best thrombolysis effect. In contrast, catheter-directed aspiration thrombectomy (group E) is effective but not safe.
conclusionsCDT with combination of pump infusion and pulse injection of pro-UK safely and significantly improves thrombolysis procedure in rabbits, suggesting potential benefits from the use of CDT in proximal DVT.
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