ArticleAnnals of translational medicine2018
Study on the relationship between age and the concentrations of heavy metal elements in human bone.
Article in Annals of translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
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- Reference Intervals for Trace Elements in Canine Plasma.Animals : an open access journal from MDPI · 2026Article
- Metals and metalloids concentrations in adults aged 50 and older from Mexico.Research square · 2025Article
- Association of urinary metal exposure with H. pylori seropositivity and mortality in the U.S. Population: NHANES 1999-2000 analysis.BMC gastroenterology · 2025Article
- Metallomic profiles of pregnant women living with obesity in the UK: a secondary analysis of UPBEAT.Metallomics : integrated biometal science · 2025Article
- Dietary Aluminum Exposure Is More Closely Linked to Antioxidant Dynamics than to Body Mass Index.Toxics · 2025Article
- Associations between plasma and urinary heavy metal concentrations and the risk of prostate cancer.Scientific reports · 2025Article
- Metal mixtures and adiposity indicators in women from Northern Mexico.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Constitutive Models for Active Skeletal Muscle: Review, Comparison, and Application in a Novel Continuum Shoulder Model.International journal for numerical methods in biomedical engineering · 2025Review
- Distinct Clusters of Testosterone Levels, Symptoms, and Serum Trace Elements in Young Men: A Cross-Sectional Analysis.Nutrients · 2025Article
- Analysis of the association between mixed exposure to multiple metals and comorbidity of osteopenia or osteoporosis: baseline data from the Chinese Multi-Ethnic Cohort study (CMEC).BMC public health · 2025Article
- The role of age and sex in non-linear dilution adjustment of spot urine arsenic.BMC nephrology · 2024Article
- Article
- Evaluation of Arsenic and Cobalt Levels in Pediatric Patients Receiving Long-Term Parenteral Nutrition.Nutrients · 2024Article
- Blood Concentration of Macro- and Microelements in Women Who Are Overweight/Obesity and Their Associations with Serum Biochemistry.Life (Basel, Switzerland) · 2024Article
- Evaluation of Environmental Contamination by Heavy Metals and Relationship with Cardiovascular Risk in a Population of Barcarena-PA.Cardiovascular toxicology · 2024Article
- Article
- Review
- Influence of heavy metals in Parkinson's disease: an overview.Journal of neurology · 2022Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExcessive amounts of heavy metals such as cadmium, chromium, cobalt, lead, thallium, and manganese are extremely harmful to the human body. These elements can accumulate in bone and impact bone metabolism. In this study, we investigated the relationship between age and the concentrations of these elements in human bone and blood.
methodsBone and blood samples were obtained from both older and younger patients. The concentrations of the elements under investigation were measured by inductively coupled plasma mass spectrometry (ICP-MS), and the specific concentrations in the bone and blood were then calculated.
resultsThe results showed that with increasing age, the concentrations of chromium, cobalt, and thallium in bone decreased significantly, while the concentration of cadmium in bone markedly increased. However, there was no clear correlation between age and the concentrations of these heavy metals in blood. Notably, there was a close correlation between the concentration of cobalt in bone and the presence of osteopenia.
conclusionsSenescence of the human body is accompanied by the shifting of cobalt, chromium, and thallium from the bone to the outer- bone. However, the concentration of cadmium in bone increases with age. These changes are very likely to be related to the equilibrium of bone metabolism in senescent individuals. In addition, only cobalt was shown to be significantly related to osteopenia.
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