ArticleJournal of pesticide science2017
The invertebrate pharmacology of insecticides acting at nicotinic acetylcholine receptors.
Article in Journal of pesticide science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 82 citations in OpenAlex.
- Biopesticidal Potential of theInternational journal of molecular sciences · 2026Article
- Assessing species-specific neonicotinoid toxicity using cross-species chimeric nicotinic acetylcholine receptors in a Drosophila model.Scientific reports · 2025Article
- Flupyradifurone, imidacloprid and clothianidin disrupt the auditory processing in the locust CNS.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Untreated plant waste of the Mediterranean region as bioadsorbent of persistent organic pollutants.Heliyon · 2024Article
- Article
- Nicotinic Acetylcholine Receptor Alpha6 Contributes to Antiviral Immunity via IMD Pathway inViruses · 2024Article
- Biological and computational evaluation of novel benzofuranyl derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.Future medicinal chemistry · 2024Article
- (-)-Adaline from theMolecules (Basel, Switzerland) · 2022Article
- Physiological and metabolic alterations induced by commercial neonicotinoid formulations in Daphnia magna.Ecotoxicology (London, England) · 2022Article
- Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications.Biomolecules · 2022Review
- Nicotinic acetylcholine receptor modulator insecticides act on diverse receptor subtypes with distinct subunit compositions.PLoS genetics · 2022Article
- Discovery of a gene cluster for the biosynthesis of novel cyclic peptide compound, KK-1, inFrontiers in fungal biology · 2022Article
- Physiological Effects of Neonicotinoid Insecticides on Non-Target Aquatic Animals-An Updated Review.International journal of molecular sciences · 2021Review
- Article
- Application of computational methods in the analysis of pesticide target-site and resistance mechanisms.Journal of pesticide science · 2021Article
- Change the channel: CysLoop receptor antagonists from nature.Pest management science · 2021Review
- Exposure to low doses of pesticides induces an immune response and the production of nitric oxide in honeybees.Scientific reports · 2021Article
- Thiamethoxam exposure deregulates short ORF gene expression in the honey bee and compromises immune response to bacteria.Scientific reports · 2021Article
- Evolutionary trade-offs of insecticide resistance - The fitness costs associated with target-site mutations in the nAChR of Drosophila melanogaster.Molecular ecology · 2020Article
- Differential metabolism of neonicotinoids byJournal of pesticide science · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel composed of 5 protein subunits arranged around a central cation selective pore. Several classes of natural and synthetic insecticides mediate their effect through interacting at nAChRs. This review examines the basic pharmacology of the neonicotinoids and related chemistry, with an emphasis on sap-feeding insects from the order Hemiptera, the principle pest target for such insecticides. Although the receptor subunit stoichiometry for endogenous invertebrate nAChRs is unknown, there is clear evidence for the existence of distinct neonicotinoid binding sites in native insect preparations, which reflects the predicted wide repertoire of nAChRs and differing pharmacology within this insecticide class. The spinosyns are principally used to control chewing pests such as Lepidoptera, whilst nereistoxin analogues are used on pests of rice and vegetables through contact and systemic action, the pharmacology of both these insecticides is unique and different to that of the neonicotinoids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.