ArticleMovement disorders clinical practice2014
Can Isolated Enlarged Virchow-Robin Spaces Influence the Clinical Manifestations of Parkinson's Disease?
Article in Movement disorders clinical practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Imaging perivascular space structure and function using brain MRI.NeuroImage · 2022Review
- The role of brain perivascular space burden in early-stage Parkinson's disease.NPJ Parkinson's disease · 2021Article
- MRI-visible perivascular spaces are associated with cerebrospinal fluid biomarkers in Parkinson's disease.Aging · 2020Article
- Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System.Frontiers in neuroanatomy · 2020Review
- Dilated Virchow-Robin space and Parkinson's disease: A case report of combined MRI and diffusion tensor imaging.Radiology case reports · 2018Article
- Levodopa-Responsive Parkinsonism Associated with Giant Virchow-Robin Spaces: A Case Report.Movement disorders clinical practiceArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dilated Virchow-Robin (VR) spaces are usually not considered to be symptomatic. We present three cases presenting with atypical clinical features, which otherwise had clinical/imaging findings consistent with idiopathic Parkinson's disease. In all cases, an isolated large VR space in the basal ganglia contralateral to the side of symptom onset was observed. We propose that the atypical features could be associated with the mass effect of a significantly enlarged VR space, which would cause a dysfunction downstream from the presynaptic nigrostriatal dopaminergic system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.