Evidence map›Paper›PMID 30363711›Full record

ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2018

Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: A Modified Delphi Consensus Process.

Antonia S Stang, Melanie Trudeau, Otto G Vanderkooi, Bonita E Lee, Linda Chui, Xiao-Li Pang, Vanessa Allen, Carey-Ann D Burnham, David M Goldfarb, Judy MacDonald and 7 more

Abstract read
In one paragraph

Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Antonia S StangDepartments of Pediatrics, Emergency Medicine and Community Health Sciences, University of Calgary, Alberta Children's Hospital Research Institute, Calgary, Alberta, Canada.ORCID 0000-0002-6680-0620
Melanie TrudeauDepartment of Pediatrics, University of Calgary, Calgary, Alberta, Canada.
Otto G VanderkooiDepartments of Pediatrics, Microbiology, Immunology and Infectious Diseases, Pathology & Laboratory Medicine and Community Health Sciences, University of Calgary, Alberta Children's Hospital Research Institute, Calgary, Alberta, Canada.
Bonita E LeeDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Linda ChuiDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Xiao-Li PangDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Vanessa AllenPublic Health Ontario Laboratories, University of Toronto, Toronto, Ontario, Canada.
Carey-Ann D BurnhamDepartments of Pathology & Immunology, Molecular Microbiology, and Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
David M GoldfarbDepartment of Pathology and Laboratory Medicine, BC Children's Hospital, Vancouver, British Columbia, Canada.
Judy MacDonaldPopulation, Public and Indigenous Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Brendon ParsonsDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Astrid PetrichDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Frank PollariEnterics Surveillance and Population Studies Division, Centre for Food-Borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, Ontario, Canada.
Phillip I TarrDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Graham TipplesDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Ran ZhuoDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Stephen B FreedmanSections of Pediatric Emergency Medicine and Gastroenterology, Departments of Pediatrics, University of Calgary, Alberta Children's Hospital, Calgary, Alberta, Canada.ORCID 0000-0003-2319-6192

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe sought to develop diagnostic test guidance definitions for pediatric enteric infections to facilitate the interpretation of positive test results in the era of multianalyte molecular diagnostic test platforms.

methodsWe employed a systematic, two-phase, modified Delphi consensus process consisting of three web-based surveys and an expert panel face-to-face meeting. In phase 1, we surveyed an advisory panel of North American experts to select pathogens requiring diagnostic test guidance definition development. In phase 2, we convened a 14-member expert panel to develop, refine, and select the final definitions through two web-based questionnaires interspersed with a face-to-face meeting. Both questionnaires asked panelists to rate the degree to which they agreed that if the definition is met the pathogen is likely to be causative of clinical illness.

resultsThe advisory panel survey identified 19 pathogens requiring definitions. In the expert panel premeeting survey, 13 of the 19 definitions evaluated were rated as being highly likely ("agree" or "strongly agree") to be responsible for acute gastroenteritis symptoms by ≥67% of respondent panel members. The definitions for the remaining six pathogens (

conclusionsWe developed diagnostic test guidance definitions to assist healthcare providers for 17 enteric pathogens. We identified two pathogens that require further research and definition development.

Identifiers

PMID30363711
PMCPMC6180965

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.