ArticleMovement disorders clinical practice2015
Serum Ferritin Levels in Parkinson's Disease Patients with and without Restless Legs Syndrome.
Article in Movement disorders clinical practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- [Frequent neurological diseases associated with the restless legs syndrome].Der Nervenarzt · 2018Pooled it
- Mastering nocturnal jigsaws in Parkinson's disease: a dusk-to-dawn review of night-time symptoms.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Probable RBD Associates with the Development of RLS in Parkinson's Disease: A Cross-Sectional Study.Behavioural neurology · 2019Article
- Impact of Impulse Control Disorders on Sleep-Wake Regulation in Parkinson's Disease.Parkinson's disease · 2015Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe frequency of RLS in Parkinson's disease (PD) patients has been reported to be between 10% and 26%. Several hypotheses have sought to link these two diseases; however, the pathophysiology of RLS in PD patients has yet to be completely defined. Many patients with idiopathic RLS have low serum ferritin levels, which negatively influence RLS symptomatology. Our objective was to investigate the role of iron deficiency in PD patients with and without RLS.
methodsWe consecutively included 42 PD inpatients undergoing pharmacological treatment. Patients with anemia, renal insufficiency, or polyneuropathy were excluded from the study. The control group consisted of 42 PD inpatients without RLS (PD-nonRLS), matched for age and severity of PD. RLS was diagnosed clinically according to diagnostic criteria. Serum ferritin levels were measured at admission for all patients.
resultsMean serum ferritin values were 142.20 ± 91.17 ng/dL for PD patients with RLS (PD+RLS) and 160.65 ± 142.57 ng/dL in PD-nonRLS (
conclusionsThere were no significant differences in serum ferritin levels between PD+RLS and PD-nonRLS in our study. This suggests a different pathophysiology of RLS in PD patients, where iron deficiency is not necessarily observed. DA use was not found to be associated with the occurrence of RLS symptoms.
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