ArticleMovement disorders clinical practice
Limb Kinetic Apraxia Is an Independent Predictor for Quality of Life in Parkinson's Disease.
Article in Movement disorders clinical practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04725773 (Apraxia in Parkinson's Disease Patients With Deep Brain Stimulation), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Apraxia in Parkinson's Disease Patients With Deep Brain Stimulation
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Limb apraxia in Parkinson's disease and atypical parkinsonian syndromes: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Comparative effects and dose-response relationships of exercise for finger dexterity and upper-limb function in Parkinson's disease: a Bayesian network and model-based dose-response meta-analysis.Frontiers in neurology · 2026Pooled it
- Effects of anodal stimulation and motor practice on limb-kinetic apraxia in Parkinson's disease.Experimental brain research · 2022Trial
- Limb-Kinetic apraxia of legs in Parkinson's disease: Prospective clinical investigation.Clinical parkinsonism & related disorders · 2025Article
- Apraxia: From Neuroanatomical Pathways to Clinical Manifestations.Current neurology and neuroscience reports · 2024Review
- Striatal Dopamine Contributions to Skilled Motor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Striatal dopamine contributions to skilled motor learning.bioRxiv : the preprint server for biology · 2024Article
- The Effectiveness of Transcranial Magnetic Stimulation in Treating Apraxia.CNS & neurological disorders drug targets · 2024Review
- Feasibility of a combined intermittent theta-burst stimulation and video game-based dexterity training in Parkinson's disease.Journal of neuroengineering and rehabilitation · 2023Article
- Finger dexterity measured by the Grooved Pegboard test indexes Parkinson's motor severity in a tremor-independent manner.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2022Article
- Impaired Affordance Perception as the Basis of Tool Use Deficiency in Alzheimer's Disease.Healthcare (Basel, Switzerland) · 2022Article
- Combining Repetitive Transcranial Magnetic Stimulation and Video Game-Based Training to Improve Dexterity in Parkinson's Disease: Study Protocol of a Randomized Controlled Trial.Frontiers in rehabilitation sciences · 2021Article
- Deficient supplementary motor area at rest: Neural basis of limb kinetic deficits in Parkinson's disease.Human brain mapping · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpaired dexterity is a common symptom in Parkinson's disease (PD) and has been related to limb kinetic apraxia (LKA). LKA negatively influenced activities of daily living (ADL) in PD. However, the impact on quality of life (QoL) remains to be clarified, which was the aim of the current study.
methodsEighty nondemented patients with PD and 60 age-matched, sex-matched healthy individuals participated in this study. The 39-item Parkinson's Disease Questionnaire was used to measure QoL. Dexterity was assessed by the coin rotation (CR) task and the ADL-related Dexterity Questionnaire 24. Nonmotor symptoms were monitored with part I of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale, and motor symptoms were measured with parts II and III of the modified Movement Disorder Society-Unified Parkinson's Disease Rating Scale.
resultsRegression analysis revealed that dexterity scores controlled for parkinsonian motor symptoms were a strong and independent predictor of QoL in patients with PD.
conclusionThe study demonstrated that the strong association of impaired dexterity and QoL is independent of bradykinesia, thereby underscoring the clinical relevance of LKA in PD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.