Evidence map›Paper›PMID 30363435›Full record

ReviewMovement disorders clinical practice

The Skin and Parkinson's Disease: Review of Clinical, Diagnostic, and Therapeutic Issues.

Matej Skorvanek, Kailash P Bhatia

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Movement disorders clinical practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
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  16. Seborrheic Dermatitis Is Related to Motor Symptoms in Parkinson's Disease.Journal of clinical neurology (Seoul, Korea) · 2022
    Article
  17. Review
  18. Journal of fungi (Basel, Switzerland) · 2022
    Review
  19. Skin Conditions and Movement Disorders: Hiding in Plain Sight.Movement disorders clinical practice · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Matej SkorvanekDepartment of Neurology P. J. Safarik University Kosice Slovakia.
Kailash P BhatiaSobell Department of Motor Neuroscience and Movement Disorders UCL Institute of Neurology University College London London United Kingdom.
University College London · GBUniversity of Pavol Jozef Šafárik · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParkinson's disease (PD) and the skin are related in a number of ways, including clinical abnormalities of the disease itself and skin-related side effects of dopaminergic medication, pumps, and surgical therapies. Recent advances in understanding the role of α-synuclein suggest skin biopsies as a potential diagnostic or even a premotor marker of PD.

methodsThe PubMed database was searched for publications up to October 2015, and the current evidence on skin-related issues in PD was comprehensively summarized.

resultsThe evidence was summarized on the prevalence, etiology, and management of seborrheic dermatitis, sweating dysfunctions, bullous pemphigoid, and malignant melanoma, as well as therapy-related skin disorders, especially those observed in amantadine, rotigotine, apomorphine, and levodopa/carbidopa intestinal gel therapies and deep-brain stimulation. Skin biopsies evaluating the presence of α-synuclein, the density and morphology of cutaneous nerves, and skin fibroblast functions also are discussed.

conclusionsSkin disorders are a common manifestation of PD. However, the exact pathophysiology and prevalence of these disorders are not well understood, and more systematic research is needed in this regard. Peripheral tissue biopsies as a diagnostic marker of PD are an exciting avenue in future PD research, although multiple caveats and pending issues need to be solved before they can be used in routine clinical practice.

Indexed as

melanomaParkinson's diseaseskintherapyα‐synuclein

Identifiers

PMID30363435
PMCPMC6174479
OpenAlexW2509012788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.