ArticleF1000Research2018
EpiLog: A software for the logical modelling of epithelial dynamics.
Article in F1000Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Cellular patterns in Arabidopsis root epidermis emerge from gene regulatory network and diffusion dynamical feedback.NPJ systems biology and applications · 2025Article
- A novel logical model of COVID-19 intracellular infection to support therapies development.PLoS computational biology · 2022Article
- UPMaBoSS: A Novel Framework for Dynamic Cell Population Modeling.Frontiers in molecular biosciences · 2022Review
- In Silico Logical Modelling to Uncover Cooperative Interactions in Cancer.International journal of molecular sciences · 2021Review
- A Novel Hybrid Logic-ODE Modeling Approach to Overcome Knowledge Gaps.Frontiers in molecular biosciences · 2021Article
- Unifying the mechanism of mitotic exit control in a spatiotemporal logical model.PLoS biology · 2020Article
- SBML Level 3: an extensible format for the exchange and reuse of biological models.Molecular systems biology · 2020Review
- Boolean analysis of lateral inhibition.Journal of mathematical biology · 2020Article
- PhysiBoSS: a multi-scale agent-based modelling framework integrating physical dimension and cell signalling.Bioinformatics (Oxford, England) · 2019Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Cellular responses are governed by regulatory networks subject to external signals from surrounding cells and to other micro-environmental cues. The logical (Boolean or multi-valued) framework proved well suited to study such processes at the cellular level, by specifying qualitative models of involved signalling pathways and gene regulatory networks. Here, we describe and illustrate the main features of EpiLog, a computational tool that implements an extension of the logical framework to the tissue level. EpiLog defines a collection of hexagonal cells over a 2D grid, which embodies a mono-layer epithelium. Basically, it defines a cellular automaton in which cell behaviours are driven by associated logical models subject to external signals. EpiLog is freely available on the web at http://epilog-tool.org. It is implemented in Java (version ≥1.7 required) and the source code is provided at https://github.com/epilog-tool/epilog under a GNU General Public License v3.0.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.