ArticleMovement disorders clinical practice
Ventral Intermediate Nucleus Versus Zona Incerta Region Deep Brain Stimulation in Essential Tremor.
Article in Movement disorders clinical practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Enhancing precision in MRgFUS for tremor treatment: a systematic review of tractography-based VIM targeting approaches.Neurosurgical review · 2025Pooled it
- The research focus and frontiers in surgical treatment of essential tremor.Frontiers in neurology · 2024Pooled it
- Patient-Reported Feedback Suggests an Alternative Sweet Spot for Deep Brain Stimulation Programming in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Surgical Treatment of Tremor Syndromes: A Guide to the Clinician.Movement disorders clinical practice · 2026Review
- Disorders of the Basal Ganglia and Cerebellum: A Comprehensive Review of Speech Sensorimotor Symptoms and Responses to Feedback Perturbations.Neurobiology of language (Cambridge, Mass.) · 2026Review
- Current and Emerging Therapeutic Targets for Essential Tremor: A Critical Appraisal of Recent Preclinical and Clinical Studies.Movement disorders clinical practice · 2025Review
- Comparative efficacy of PSA and VIM deep brain stimulation in essential tremor: a network and multilevel meta-analysis.Neurosurgical review · 2025Review
- Unilateral deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) for the treatment of post-traumatic tremor in children: a multicentre experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Deep Brain Stimulation for Orthostatic Tremor: An Observational Study.Movement disorders clinical practice · 2024Observational
- The role of the motor thalamus in deep brain stimulation for essential tremor.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Deep brain stimulation (DBS) as a therapeutic approach in gait disorders: What does it bring to the table?IBRO neuroscience reports · 2023Review
- Technical Issues of Vim-PSA Double-Target DBS for Essential Tremor.Brain sciences · 2023Article
- Which one is the superior target? A comparison and pooled analysis between posterior subthalamic area and ventral intermediate nucleus deep brain stimulation for essential tremor.CNS neuroscience & therapeutics · 2022Article
- New Targets and New Technologies in the Treatment of Parkinson's Disease: A Narrative Review.International journal of environmental research and public health · 2022Review
- A Single DBS-Lead to Stimulate the Thalamus and Subthalamus: Two-Story Targets for Tremor Disorders.Frontiers in human neuroscience · 2022Article
- Deep Brain Stimulation for Tremor: Update on Long-Term Outcomes, Target Considerations and Future Directions.Journal of clinical medicine · 2021Review
- Habituation After Deep Brain Stimulation in Tremor Syndromes: Prevalence, Risk Factors and Long-Term Outcomes.Frontiers in neurology · 2021Review
- Deep-Brain Stimulation for Essential Tremor and Other Tremor Syndromes: A Narrative Review of Current Targets and Clinical Outcomes.Brain sciences · 2020Review
- Neuroimaging Advances in Deep Brain Stimulation: Review of Indications, Anatomy, and Brain Connectomics.AJNR. American journal of neuroradiology · 2020Review
- Deep brain stimulation and other surgical modalities for the management of essential tremor.Expert review of medical devices · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ventral intermediate nucleus (VIM) is the target of choice for Essential Tremor (ET) deep brain stimulation (DBS). Renewed interest in caudal zona incerta (cZI) stimulation for tremor control has recently emerged and some groups believe this approach may address long-term reduction of benefit seen with VIM-DBS.
objectivesTo compare clinical outcomes and DBS programming in the long-term between VIM and cZI neurostimulation in ET-DBS patients. MATERIALS AND
methodsA retrospective review of 53 DBS leads from 47 patients was performed. Patients were classified into VIM or cZI groups according to the location of the activated DBS contact. Demographics, DBS settings, and Tremor Rating Scale scores were compared between groups at baseline and yearly follow-up to 4 years after DBS. Student t-tests and analysis of variance (ANOVA) were used to compare variables between groups.
resultsRelative to baseline, an improvement in ON-DBS tremor scores was observed in both groups from 6 months to 4 years post-DBS (
conclusionsMore ventral DBS contacts in the cZI region do improve tremor, however, VIM-DBS provided better long-term outcomes. Randomized controlled trials comparing cZI vs VIM targets should confirm these results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.