ReviewMovement disorders clinical practice
Pragmatic Treatment of Stiff Person Spectrum Disorders.
Review in Movement disorders clinical practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review of Immune and Symptomatic Treatments for Stiff-Person Syndrome.European journal of neurology · 2025Pooled it
- Exteroceptive Reflexes in Stiff Person Syndrome, Other Neurological Conditions and Healthy Controls.Movement disorders clinical practice · 2026Article
- Stiff-person syndrome following west nile virus infection in an immunocompromised patient.Journal of neurology · 2026Article
- Chimeric antigen receptor T-cell therapy for stiff-person syndrome: bridging innovation and clinical challenges in neuroimmunology.Therapeutic advances in neurological disorders · 2025Review
- Botulinum toxin in stiff person syndrome: how useful is it in helping muscle stiffness and spasms?Therapeutic advances in neurological disorders · 2025Article
- Stiff-person syndrome and related disorders - diagnosis, mechanisms and therapies.Nature reviews. Neurology · 2024Review
- Progressive encephalomyelitis with rigidity and myoclonus: a pediatric case report and literature review.BMC pediatrics · 2024Review
- Axial dystonia as a manifestation of stiff-person syndrome in a paediatric patient.BMJ case reports · 2024Article
- Stiff Person Spectrum Disorders-An Update and Outlook on Clinical, Pathophysiological and Treatment Perspectives.Biomedicines · 2023Review
- Relevance of Antibody Testing in Movement Disorders.Movement disorders clinical practice · 2023Article
- COVID-19 Still Surprising Us-A Rare Movement Disorder Induced by Infection.Brain sciences · 2022Article
- One in a Million: A Case Report of Stiff Person Syndrome.Case reports in rheumatology · 2022Article
- From Collar to Coccyx: Truncal Movement Disorders: A Clinical Review.Movement disorders clinical practice · 2021Review
- Paraneoplastic neurological syndrome: an evolving story.Neuro-oncology practice · 2021Review
- Are Antibody Panels Under-Utilized in Movement Disorders Diagnosis? Yes.Movement disorders clinical practice · 2021Article
- Are Antibody Panels Under-Utilized in Movement Disorders Diagnosis? No.Movement disorders clinical practice · 2021Article
- Involuntary movement in stiff-person syndrome with amphiphysin antibodies: A case report.Medicine · 2021Article
- Treatable Hyperkinetic Movement Disorders Not to Be Missed.Frontiers in neurology · 2021Review
- Effectiveness of Combined Immunoglobulin and Glucocorticoid Treatments in a Patient With Stiff Limb Syndrome: Case Report and Review of the Literature.Frontiers in neurology · 2020Article
- Trismus as a Presenting Symptom in a Case of Progressive Encephalopathy with Rigidity and Myoclonus.Case reports in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStiff person spectrum disorders (SPSD) are a group of rare conditions clinically characterized by stiffness, spasms, and heightened stimulus sensitivity. They also share a spectrum of antibodies.
methodsWe reviewed the literature and our own experience with the aim of providing a practical approach to the treatment of SPSD.
resultsBecause of the rarity of SPSD, there is little evidence to guide treatment decisions. The treatment of SPSD is based on the triad of symptomatic treatment, immunotherapy, and tumor treatment where appropriate. Moreover, the management involves continuous and appropriate monitoring of the symptoms of the disease, its autoimmune associations, and potential treatment side effects.
conclusionsHere we delineated a pragmatic treatment approach to SPSD, based on our experience and existing literature. We also highlighted how our understanding of neuronal antibodies and their implications reflects on management considerations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.