ReviewMovement disorders clinical practice
Deep Brain Stimulation for the Dystonias: Evidence, Knowledge Gaps, and Practical Considerations.
Review in Movement disorders clinical practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Human and mouse cerebellar inhibitory circuits in dystonic crisis and their modulation with therapeutic stimulation.bioRxiv : the preprint server for biology · 2026Article
- Transcriptomic disruption and hypoactivity in DYT-SGCE medial ganglionic eminence-patterned inhibitory neurons.Brain : a journal of neurology · 2026Article
- Engaging dystonia networks with subthalamic stimulation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comparison of different surgical strategies for cervical dystonia: Evidence from Bayesian network analysis.European journal of neurology · 2025Article
- A framework for translational therapy development in deep brain stimulation.NPJ Parkinson's disease · 2024Review
- Review
- Engaging dystonia networks with subthalamic stimulation.medRxiv : the preprint server for health sciences · 2024Article
- Suicide Attempt in a Poststroke Patient After Undergoing Deep Brain Stimulation: A Case Report.Cureus · 2024Article
- Directional Stimulus-Evoked Pallidal Electrophysiology in Primary Dystonia.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Deep Brain Stimulation for the Management of Refractory Neurological Disorders: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2023Review
- Changes in deep brain stimulation surgeries between 2019 and 2020: A national inpatient sample analysis.World neurosurgery: X · 2023Article
- Neuromodulation in Dystonia - Harnessing the Network.Advances in neurobiology · 2023Article
- Case report: Unilateral GPi DBS in secondary myoclonus-dystonia syndrome after acute disseminated encephalomyelitis.Frontiers in neurology · 2023Article
- Functional Movement Disorders and Deep Brain Stimulation: A Multi-Center Study.Movement disorders clinical practice · 2023Article
- Applicability of clinical genetic testing for deep brain stimulation treatment in monogenic Parkinson's disease and monogenic dystonia: a multidisciplinary team perspective.Frontiers in neuroscience · 2023Article
- DBS emergency surgery for treatment of dystonic storm associated with rhabdomyolysis and acute colitis in DYT-GNAO1.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- GPi-DBS forMovement disorders clinical practice · 2022Review
- Predicting Outcome in a Cohort of Isolated and Combined Dystonia within Probabilistic Brain Mapping.Movement disorders clinical practice · 2021Article
- Correlates of deep brain stimulation consensus conference decision to treat primary dystonia.Clinical neurology and neurosurgery · 2021Article
- Generalized Dystonia Treated With Deep Brain Stimulator: An Institutional Single Surgeon Experience.Cureus · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeep brain stimulation (DBS) of the globus pallidus internus (GPi-DBS) is among the most effective treatment options for dystonias. Because the term "dystonia" is defined by a characteristic phenomenology of involuntary muscle contractions, which may present with a large clinical and pathogenetic heterogeneity, decision making for or against GPi-DBS can be difficult in individual patients.
methodsA search of the PubMed database for research and review articles, focused on "deep brain stimulation" and "dystonia" was used to identify clinical trials and to determine current concepts in the surgical management of dystonia. Patient selection in previous studies was recategorized by the authors using the new dystonia classification put forward by a consensus committee of experts in dystonia research. The evidence and knowledge gaps are summarized and commented by the authors taking into account expert opinion and personal clinical experience for providing practical guidance in patient selection for DBS in dystonia.
resultsThe literature review shows that pallidal deep brain stimulation is most effective in patients with isolated dystonia irrespective of the underlying etiology. In contrast, patients with combined dystonias are less likely to benefit from DBS, because the associated neurological symptoms (e.g., hypotonia or ataxia), with the exception of myoclonus, do not respond to pallidal neurostimulation.
conclusionsIt is important to recognize the clinical features of dystonia, because the distinction between isolated and combined dystonia syndromes may predict the treatment response to pallidal deep brain stimulation. The aim of this review is to help guide clinicians with advising patients about deep brain stimulation therapy for dystonia and refering appropriate candidates to surgical centers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.