Evidence map›Paper›PMID 30363025›Full record

Trial reportSexually transmitted diseases2019

Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting.

Anthony D Cristillo, Claire C Bristow, Elizabeth Torrone, Jo-Anne Dillon, Robert D Kirkcaldy, Huan Dong, Yonatan H Grad, Robert A Nicholas, Peter A Rice, Kenneth Lawrence and 6 more

Open access · hybridAbstract readClinical Trial
In one paragraph

Trial report in Sexually transmitted diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Identification of Emerging Multidrug-ResistantMedical sciences (Basel, Switzerland) · 2023
    Article
  5. Screening of Antimicrobial Properties and Bioactive Compounds ofBiochemistry research international · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Prevalence and Antimicrobial Susceptibility Patterns ofInternational journal of microbiology · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 3 countries.

Anthony D Cristillo
Claire C BristowDepartment of Medicine, University of California San Diego School of Medicine, La Jolla, CA.
Elizabeth TorroneDivision of STD Prevention, US Centers for Disease Control and Prevention (CDC), Atlanta, GA.
Jo-Anne DillonDepartment of Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatchewan, Canada.
Robert D KirkcaldyDivision of STD Prevention, US Centers for Disease Control and Prevention (CDC), Atlanta, GA.
Huan Dong
Yonatan H GradDepartment of Immunology and Infectious Diseases, Harvard University T.H. Chan School of Public Health, Boston, MA.
Robert A NicholasDepartment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Peter A RiceDepartment of Medicine, University of Massachusetts Medical School, Worcester, MA.
Kenneth LawrenceClinical Operations, Entasis Therapeutics, Waltham, MA.
David OldachCempra Pharmaceuticals, Chapel Hill, NC.
William Maurice Shafer
Pei ZhouDepartment of Biochemistry, Duke University Medical Center, Durham, NC.
Teodora E WiDepartment of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
Sheldon R MorrisDepartment of Medicine, University of California San Diego School of Medicine, La Jolla, CA.
Jeffrey D KlausnerDivision of Infectious Diseases, University of California, Los Angeles, Los Angeles, CA.
Centers for Disease Control and Prevention · USUniversity of California, San Diego · USCempra Pharmaceuticals (United States) · USDuke Medical Center · USEntasis Therapeutics (United States) · USHarvard University · USSocial and Scientific Systems (United States) · USUniversity of California, Los Angeles · USUniversity of Massachusetts Chan Medical School · USUniversity of North Carolina at Chapel Hill · USUniversity of Saskatchewan · CAWorld Health Organization · CH

Funding

University of California Launching Future Leaders in Global Health Research Training ProgramD43TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIG R COHEN, Sung-Jae Lee · 2017 to 2026
$14.7M
LpxC inhibitors as a novel class of antibiotics against N. gonorrhoeaeR01AI094475 · NIAID · DUKE UNIVERSITY · PI NICHOLAS, ROBERT A, ZHOU, PEI · 2011 to 2015
$3.7M
Biochemistry and Structure of Lipid A EnzymesR01GM115355 · NIGMS · DUKE UNIVERSITY · PI ZHOU, PEI · 2016 to 2019
$1.2M
Controlling Drug Resistant Gonorrhea with Real-Time PCR Susceptibility TestingR21AI109005 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KLAUSNER, JEFFREY DAVID · 2014 to 2015
$362k
FIC NIH HHS D43 TW009343Intramural CDC HHS CC999999NIAID NIH HHS HHSN272201300014INIAID NIH HHS R01 AI094475NIAID NIH HHS R21 AI109005NIGMS NIH HHS R01 GM115355World Health Organization 001
6 · The paper itself

Abstract

The goal of the Sexually Transmitted Infection Clinical Trial Group's Antimicrobial Resistance (AMR) in Neisseria gonorrhoeae (NG) meeting was to assemble experts from academia, government, nonprofit and industry to discuss the current state of research, gaps and challenges in research and technology and priorities and new directions to address the continued emergence of multidrug-resistant NG infections. Topics discussed at the meeting, which will be the focus of this article, include AMR NG global surveillance initiatives, the use of whole genome sequencing and bioinformatics to understand mutations associated with AMR, mechanisms of AMR, and novel antibiotics, vaccines and other methods to treat AMR NG. Key points highlighted during the meeting include: (i) US and International surveillance programs to understand AMR in NG; (ii) the US National Strategy for combating antimicrobial-resistant bacteria; (iii) surveillance needs, challenges, and novel technologies; (iv) plasmid-mediated and chromosomally mediated mechanisms of AMR in NG; (v) novel therapeutic (eg, sialic acid analogs, factor H [FH]/Fc fusion molecule, monoclonal antibodies, topoisomerase inhibitors, fluoroketolides, LpxC inhibitors) and preventative (eg, peptide mimic) strategies to combat infection. The way forward will require renewed political will, new funding initiatives, and collaborations across academic and commercial research and public health programs.

Indexed as

Drug Resistance, Multiple, BacterialGroup ProcessesAnti-Bacterial AgentsAntimicrobial StewardshipBacterial VaccinesBarbituratesEpidemiological MonitoringGonorrheaHumansIsoxazolesMacrolidesMicrobial Sensitivity TestsMorpholinesMutationNeisseria gonorrhoeaeOxazolidinonesAnti-Bacterial AgentsBacterial VaccinesBarbituratesIsoxazolesMacrolidesMorpholinesOxazolidinonessolithromycinSpiro CompoundsTopoisomerase InhibitorsTriazoleszoliflodacin

Identifiers

PMID30363025
PMCPMC6370498
OpenAlexW2898445135

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.