Evidence map›Paper›PMID 30362963›Full record

ArticleAging2018

Nuclear Nox4 interaction with prelamin A is associated with nuclear redox control of stem cell aging.

Francesca Casciaro, Francesca Beretti, Manuela Zavatti, James A McCubrey, Stefano Ratti, Sandra Marmiroli, Matilde Y Follo, Tullia Maraldi

Open access · greenAbstract read
In one paragraph

Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Psychological Stress and Cellular Aging in Cancer: A Meta-Analysis.Oxidative medicine and cellular longevity · 2019
    Pooled it
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  12. The Interplay between HGF/c-met Axis and Nox4 in BRAF Mutated Melanoma.International journal of molecular sciences · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Francesca CasciaroDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, 41124, Italy.
Francesca BerettiDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, 41124, Italy.
Manuela ZavattiDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, 41124, Italy.
James A McCubreyDepartment of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA.
Stefano RattiCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, 40126, Italy.
Sandra MarmiroliCellular Signaling Unit, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, 41125, Italy.
Matilde Y FolloCellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, 40126, Italy.
Tullia MaraldiDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, 41124, Italy.
University of Modena and Reggio Emilia · ITUniversity of Bologna · ITEast Carolina University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells have emerged as an important tool that can be used for tissue regeneration thanks to their easy preparation, differentiation potential and immunomodulatory activity. However, an extensive culture of stem cells

Indexed as

Cellular SenescenceOxidative StressAdultAmniotic FluidCell NucleusCell ProliferationCells, CulturedFemaleGene Expression RegulationHumansLamin Type AMesenchymal Stem CellsNADPH Oxidase 4Oxidation-ReductionPhenotypePregnancyLamin Type ANADPH Oxidase 4NOX4 protein, humanprelamin AAFSCNox4nuclear ROSprelaminsenescence

Identifiers

PMID30362963
PMCPMC6224265
OpenAlexW2898422856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.