Evidence map›Paper›PMID 30362940›Full record

ArticleeLife2018

Chromatin accessibility dynamics across

Jürgen Jänes, Yan Dong, Michael Schoof, Jacques Serizay, Alex Appert, Chiara Cerrato, Carson Woodbury, Ron Chen, Carolina Gemma, Ni Huang and 6 more

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed.

  1. Article
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  11. The Binding Landscape of an Essential Nuclear Hormone Receptor inbioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. A scheduler for rhythmic gene expression.Molecular systems biology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Aberrant X chromosome dosage compensation causes hybrid male inviability inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. A scheduler for rhythmic gene expression.bioRxiv : the preprint server for biology · 2025
    Article
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jürgen Jänes *Department of Genetics, University of Cambridge, Cambridge, United Kingdom.ORCID http://orcid.org/0000-0002-2540-1236
Yan Dong *Department of Genetics, University of Cambridge, Cambridge, United Kingdom.
Michael Schoof *Department of Genetics, University of Cambridge, Cambridge, United Kingdom.
Jacques Serizay *Department of Genetics, University of Cambridge, Cambridge, United Kingdom.
Alex AppertDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Chiara CerratoDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Carson WoodburyDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Ron ChenDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Carolina GemmaDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Ni HuangDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.ORCID http://orcid.org/0000-0001-8849-038X
Djem KissiovDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Przemyslaw StemporDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.ORCID http://orcid.org/0000-0002-9464-7475
Annette StewardDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Eva ZeiserDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.
Sascha SauerMax Delbrück Center for Molecular Medicine, Berlin, Germany.
Julie AhringerDepartment of Genetics, University of Cambridge, Cambridge, United Kingdom.ORCID http://orcid.org/0000-0002-7074-4051

Funding

Cancer Research UK C6946/A14492Medical Research CouncilWellcome TrustWellcome Trust 054523Wellcome Trust 092096Wellcome Trust 097679Wellcome Trust 101863Wellcome Trust 97679
6 · The paper itself

Abstract

An essential step for understanding the transcriptional circuits that control development and physiology is the global identification and characterization of regulatory elements. Here, we present the first map of regulatory elements across the development and ageing of an animal, identifying 42,245 elements accessible in at least one

Indexed as

AgingAnimalsCaenorhabditis elegansChromatinDNAEnhancer Elements, GeneticGene Expression Regulation, DevelopmentalHistone CodeHistonesMolecular Sequence AnnotationPromoter Regions, GeneticReproducibility of ResultsTranscription FactorsTranscription Initiation SiteChromatinDNAHistonesTranscription FactorsATAC-seqC. eleganschromatin accessibilitychromosomesenhancergene expressiongeneticsgenomicspromoterregulatory element

Identifiers

PMID30362940
PMCPMC6231769

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.