Evidence map›Paper›PMID 30362876›Full record

Trial reportJournal of neurotrauma2019

Self-Assisted Standing Enabled by Non-Invasive Spinal Stimulation after Spinal Cord Injury.

Dimitry G Sayenko, Mrinal Rath, Adam R Ferguson, Joel W Burdick, Leif A Havton, V Reggie Edgerton, Yury P Gerasimenko

3 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurotrauma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 164 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 9 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04807764 nacompletednot on this mapstarted 2021, after this paper: background citation

Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury

TypeinterventionalSponsorCity University of New YorkRan2021 to 2024Enrolled14ConditionsSpinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis, Paraplegia, SpasticArmsStanding transspinal stimulation followed by robotic gait training, Lying transspinal stimulation followed by robotic gait training, Standing sham transspinal stimulation followed by robotic gait training
NCT05115149 naunknown statusnot on this mapstarted 2021, after this paper: background citation

The Study on the еffectiveness of the Integration of a Device Based on a Neural Interface and Neurostimulation of the Spinal Cord in the Rehabilitation of Patients With Upper Limb Movement Impairments Due to Neurological Disorders.

TypeinterventionalSponsorSkolkovo Institute of Science and TechnologyRan2021 to 2023Enrolled60ConditionsStroke, Spinal Cord InjuriesArmsVIBRAINT RehUp robotic orthosis, tSCS during the exercise, tSCS prior to the exercise, Neostim-5, Exercise
NCT06213012 narecruitingnot on this mapstarted 2023, after this paper: background citation

Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury

TypeinterventionalSponsorThe Methodist Hospital Research InstituteRan2023 to 2027Enrolled60ConditionsSpinal Cord Injuries, NeuromodulationArmsTranscutaneous Spinal cord Stimulation, Epidural Spinal Stimulation (ESS)
3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 9 syntheses or guidelines pooled it, 230 citations in OpenAlex.

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104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Dimitry G Sayenko1 Department of Integrative Biology and Physiology, University of California, Los Angeles, California.
Mrinal Rath1 Department of Integrative Biology and Physiology, University of California, Los Angeles, California.
Adam R Ferguson4 Brain and Spinal Injury Center, Department of Neurological Surgery, University of California, San Francisco, California.
Joel W Burdick5 Division of Engineering and Applied Sciences, California Institute of Technology, Pasadena, California.
Leif A Havton6 Departments of Neurology and Neurobiology, University of California, Los Angeles, California.
V Reggie Edgerton1 Department of Integrative Biology and Physiology, University of California, Los Angeles, California.
Yury P Gerasimenko1 Department of Integrative Biology and Physiology, University of California, Los Angeles, California.
University of California, Los Angeles · USCalifornia Institute of Technology · USHouston Methodist · USUniversity of Technology Sydney · AU

Funding

A Theranostic Tool to Assess and Enable Spared Spinal Motor Function After SCIR43EB018232 · NIBIB · NEUROENABLING TECHNOLOGIES, INC. · PI EDGERTON, REGGIE, LU, DANIEL · 2013 to 2014
$692k
NIBIB NIH HHS R43 EB018232
6 · The paper itself

Abstract

Neuromodulation of spinal networks can improve motor control after spinal cord injury (SCI). The objectives of this study were to (1) determine whether individuals with chronic paralysis can stand with the aid of non-invasive electrical spinal stimulation with their knees and hips extended without trainer assistance, and (2) investigate whether postural control can be further improved following repeated sessions of stand training. Using a double-blind, balanced, within-subject cross-over, and sham-controlled study design, 15 individuals with SCI of various severity received transcutaneous electrical spinal stimulation to regain self-assisted standing. The primary outcomes included qualitative comparison of need of external assistance for knee and hip extension provided by trainers during standing without and in the presence of stimulation in the same participants, as well as quantitative measures, such as the level of knee assistance and amount of time spent standing without trainer assistance. None of the participants could stand unassisted without stimulation or in the presence of sham stimulation. With stimulation all participants could maintain upright standing with minimum and some (

Indexed as

Standing PositionAdultDouble-Blind MethodElectromyographyFemaleHumansMaleMiddle AgedMuscle, SkeletalSpinal Cord InjuriesSpinal Cord Stimulationbalance controlneuromodulationneuroplasticityparalysistranscutaneous electrical spinal cord stimulation

Identifiers

PMID30362876
PMCPMC6482915
OpenAlexW2898125561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.