ArticleThe British journal of radiology2019
Exploring the feasibility of a clinical proton beam with an adaptive aperture for pre-clinical research.
Article in The British journal of radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Evaluation of a Dynamic Collimation System to Improve IMPT Dose Distributions and Maintain Treatment Efficiency.Cancers · 2026Article
- Design, fabrication, commissioning, and dosimetric verification of a GRID collimator for proton SFRT on a compact proton therapy machine.Medical physics · 2025Article
- Virtual monoenergetic micro-CT imaging in mice with artificial intelligence.Scientific reports · 2022Article
- Comparison of the [Molecular imaging and biology · 2021Article
- Deep Learning Based Automated Orthotopic Lung Tumor Segmentation in Whole-Body Mouse CT-Scans.Cancers · 2021Article
- Innovations and the Use of Collimators in the Delivery of Pencil Beam Scanning Proton Therapy.International journal of particle therapy · 2021Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objective: To investigate whether the Mevion S250i with HYPERSCAN clinical proton system could be used for pre-clinical research with millimetric beams.
methods: The nozzle of the proton beam line, consisting of an energy modulation system (EMS) and an adaptive aperture (AA), was modelled with the TOPAS Monte Carlo Simulation Toolkit. With the EMS, the 230 MeV beam nominal range can be decreased in multiples of 2.1 mm. Monte Carlo dose calculations were performed in a mouse lung tumour CT image. The AA allows fields as small as 5 × 1 mm
results: Seven different proton beam plans were investigated, with a good coverage to the tumour (D95 > 1.95 Gy, D5 < 2.3 Gy) and with potentially less damage to the organs at risk than the photon plan. For very small fields and low energies, the number of protons arriving to the target drops to 1-3%, nevertheless the treatment times would be below 5 s.
conclusion: The proton plans made in this study, collimated by an AA, could be used for animal irradiation. ADVANCES IN KNOWLEDGE:: This is one of the first study to demonstrate the feasibility of pre-clinical research with a clinical proton beam with an adaptive aperture used to create small fields.
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