Evidence map›Paper›PMID 30362108›Full record

ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2019

Precancerous cervical lesions and HPV genotypes identified in previously unsatisfactory cervical smear tests after inexpensive glacial acetic acid processing.

Carolann Risley, Kim R Geisinger, Jennifer C Robinson, Mary W Stewart, Lei Zhang, Rhonda Alexander, Stephen S Raab

Erratum issuedAbstract read
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Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Carolann RisleySchool of Graduate Studies and School of Nursing, University of Mississippi Medical Center, Jackson, MI, USA.
Kim R GeisingerSchool of Graduate Studies and School of Nursing, University of Mississippi Medical Center, Jackson, MI, USA.
Jennifer C RobinsonSchool of Graduate Studies and School of Nursing, University of Mississippi Medical Center, Jackson, MI, USA.
Mary W StewartSchool of Graduate Studies and School of Nursing, University of Mississippi Medical Center, Jackson, MI, USA.
Lei ZhangSchool of Graduate Studies and School of Nursing, University of Mississippi Medical Center, Jackson, MI, USA.
Rhonda AlexanderSchool of Graduate Studies and School of Nursing, University of Mississippi Medical Center, Jackson, MI, USA.
Stephen S RaabSchool of Graduate Studies and School of Nursing, University of Mississippi Medical Center, Jackson, MI, USA.

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2016 to 2025
$38.2M
NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

objectiveTo determine the effectiveness of using glacial acetic acid (GAA) to convert unsatisfactory bloody ThinPrep (TP) cervical smear test to satisfactory, and identify associated missed diagnoses and high-risk HPV (hrHPV) genotypes.

methodsIn a retrospective descriptive cross-sectional analysis, all TP tests performed in Mississippi, USA, 2012-2016, were evaluated for unsatisfactory results owing to blood. Tests that were converted to satisfactory by GAA treatment, and corresponding anomalies and HPV genotypes were identified.

resultsAmong 106 384 TP tests, there were 1460 (1.37%) unsatisfactory results, of which 1442 (98.77%) were converted to satisfactory after GAA treatment. Laboratory preprocessing with GAA increased costs minimally. Precancerous lesions were detected in 166 (11.51%) of 1442 GAA-treated samples, of which 12 (7.2%) were high-grade lesions, 110 (66.3%) were atypical squamous cells of undetermined significance, and 63 (57.3%) tested positive for hrHPV. Of 60 genotyped samples, 39 (65%) had non-HPV16 and non-HPV18. Including mixed infections, 48 (80%) contained less-common hrHPV types, reflecting an unexpected distribution in bloody specimens.

conclusionsGAA pretreatment of bloody TP tests would reduce the incidence of unsatisfactory results and missed high-grade lesions, and prevent the cost of repeat tests and delayed treatment. Clinicians without access to GAA should consider HPV testing.

Indexed as

Acetic AcidIndicators and ReagentsAdultCross-Sectional StudiesFemaleGenotypeHuman Papillomavirus DNA TestsHumansMiddle AgedPapillomaviridaePapillomavirus InfectionsRetrospective StudiesSensitivity and SpecificityUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsAcetic AcidIndicators and ReagentsASC-USBloody cervical smear specimensCervical cancerCervical smear testGlacial acetic acidHigh-risk HPVHPV genotypesUnsatisfactory cervical smear specimens

Identifiers

PMID30362108
PMCPMC6431532

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