Evidence map›Paper›PMID 30362089›Full record

ReviewAdvances in experimental medicine and biology

Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis.

Ying Chen, Ming Han, Akiko Matsumoto, Yewei Wang, David C Thompson, Vasilis Vasiliou

Open access · greenAbstract readReview
In one paragraph

Review in Advances in experimental medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The Role of Glutathione in Selected Viral Diseases.Antioxidants (Basel, Switzerland) · 2023
    Review
  10. DNA Methylation in Alcohol Use Disorder.International journal of molecular sciences · 2023
    Review
  11. Review
  12. Alcohol and breast cancer.Pharmacological reports : PR · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Redox Imbalance and Methylation Disturbances in Early Childhood Obesity.Oxidative medicine and cellular longevity · 2021
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Ying ChenDepartment of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA. ying.chen@yale.edu.
Ming HanDepartment of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA.
Akiko MatsumotoDepartment of Social Medicine, Saga University School of Medicine, Saga, Japan.
Yewei WangDepartment of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA.
David C ThompsonDepartment of Clinical Pharmacy, University of Colorado School of Pharmacy, Aurora, CO, USA.
Vasilis VasiliouDepartment of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA.
Yale University · USSaga University · JPShanxi University · CNUniversity of Colorado Denver · US

Funding

Mouse Models for Alcohol Metabolism and Tissue InjuryR24AA022057 · NIAAA · YALE UNIVERSITY · PI VASILIOU, VASILIS · 2013 to 2022
$4.5M
The role of ALDH1B1 in ethanol metabolism and colon cancerU01AA021724 · NIAAA · YALE UNIVERSITY · PI VASILIOU, VASILIS · 2014 to 2017
$1.7M
Novel Redox-Associated Mechanisms Preventing Alcoholic Fatty LiverK01AA025093 · NIAAA · YALE UNIVERSITY · PI CHEN, YING · 2016 to 2019
$702k
NIAAA NIH HHS K01 AA025093NIAAA NIH HHS R24 AA022057NIAAA NIH HHS U01 AA021724
6 · The paper itself

Abstract

Glutathione (GSH) is the most abundant non-protein thiol, attaining cellular concentrations in the millimolar range. GSH functions to protect cells against endogenous and exogenous electrophiles. In addition, GSH serves as a cofactor for the GSH peroxidase family of enzymes which metabolize H

Indexed as

CarcinogenesisEthanolGlutathioneGlutathione TransferaseHumansHydrogen PeroxideMethylationReactive Oxygen SpeciesEthanolGlutathioneGlutathione TransferaseHydrogen PeroxideReactive Oxygen SpeciesAlcoholicCancerGlutathioneMethylationOxidative stressTranssulfuration

Identifiers

PMID30362089
PMCPMC6743726
OpenAlexW2898565404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.