Trial reportAnnals of biomedical engineering2019
Impact of Pulmonary Venous Inflow on Cardiac Flow Simulations: Comparison with In Vivo 4D Flow MRI.
Trial report in Annals of biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- Development and Initial Validation of the Novel Computational Method for Dynamic Intracardiac Blood Flow Evaluation.Diagnostics (Basel, Switzerland) · 2026Article
- Systematic computational assessment of atrial function impairment due to fibrotic remodeling in electromechanical properties.PLoS computational biology · 2025Article
- Morphotype-based risk stratification in patients with patent foramen ovale using computational fluid dynamics.Scientific reports · 2025Article
- Hemodynamics affects factor XI/XII anticoagulation efficacy in patient-derived left atrial models.Computer methods and programs in biomedicine · 2025Article
- Left atrial wall shear stress correlates with fibrosis in patients with atrial fibrillation.Nature cardiovascular research · 2025Observational
- Targeted Rapamycin Delivery via Magnetic Nanoparticles to Address Stenosis in a 3D Bioprinted in Vitro Model of Pulmonary Veins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Numerical modeling assisting in surgical treatment of total anomalous pulmonary venous connection in children.World journal of pediatric surgery · 2024Article
- Pulmonary vein flow split effects in patient-specific simulations of left atrial flow.Computers in biology and medicine · 2023Article
- Do blood flow patterns in the left atriums differ between left upper lobectomy and other lobectomies? A computational study.Frontiers in cardiovascular medicine · 2023Article
- Elevated atrial blood stasis in paroxysmal atrial fibrillation during sinus rhythm: a patient-specific computational fluid dynamics study.Frontiers in cardiovascular medicine · 2023Article
- Fluid-Structure Interaction Model for Predicting Surgical Result of Total Anomalous Pulmonary Venous Connection and Estimating Pulmonary Venous Properties.Cardiovascular engineering and technology · 2022Article
- Dual-VENC 4D Flow MRI Can Detect Abnormal Blood Flow in the Left Atrium That Potentially Causes Thrombosis Formation after Left Upper Lobectomy.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- Non-Newtonian blood rheology impacts left atrial stasis in patient-specific simulations.International journal for numerical methods in biomedical engineering · 2022Article
- Effect of left ventricular assist device on the hemodynamics of a patient-specific left heart.Medical & biological engineering & computing · 2022Article
- On the Impact of Left Upper Lobectomy on the Left Atrial Hemodynamics.Frontiers in physiology · 2022Article
- Imaging and biophysical modelling of thrombogenic mechanisms in atrial fibrillation and stroke.Frontiers in cardiovascular medicine · 2022Review
- Demonstration of Patient-Specific Simulations to Assess Left Atrial Appendage Thrombogenesis Risk.Frontiers in physiology · 2021Article
- Numerical Simulation of Hemodynamics in Two Models for Total Anomalous Pulmonary Venous Connection Surgery.Frontiers in physiology · 2020Article
- Personalized biomechanical insights in atrial fibrillation: opportunities & challenges.Expert review of cardiovascular therapyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Blood flow simulations are making their way into the clinic, and much attention is given to estimation of fractional flow reserve in coronary arteries. Intracardiac blood flow simulations also show promising results, and here the flow field is expected to depend on the pulmonary venous (PV) flow rates. In the absence of in vivo measurements, the distribution of the flow from the individual PVs is often unknown and typically assumed. Here, we performed intracardiac blood flow simulations based on time-resolved computed tomography on three patients, and investigated the effect of the distribution of PV flow rate on the flow field in the left atrium and ventricle. A design-of-experiment approach was used, where PV flow rates were varied in a systematic manner. In total 20 different simulations were performed per patient, and compared to in vivo 4D flow MRI measurements. Results were quantified by kinetic energy, mitral valve velocity profiles and root-mean-square errors of velocity. While large differences in atrial flow were found for varying PV inflow distributions, the effect on ventricular flow was negligible, due to a regularizing effect by mitral valve. Equal flow rate through all PVs most closely resembled in vivo measurements and is recommended in the absence of a priori knowledge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.