Evidence map›Paper›PMID 30362058›Full record

ArticleJournal of assisted reproduction and genetics2018

Comparison of different types of twin pregnancies in terms of obstetric and perinatal outcomes: association of vanished twins with methylenetetrahydrofolate reductase (MTHFR) polymorphism(s).

Murat Aykut Ozek, Ergun Karaagaoglu, Gokcen Orgul, Fatma Gumruk, Murat Yurdakök, M Sinan Beksac

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Murat Aykut OzekDivision of Perinatal Medicine, Department of Obstetrics and Gynecology, Hacettepe University Medical Faculty, Ankara, Turkey. aykut.spm@gmail.com.ORCID http://orcid.org/0000-0003-2874-6958
Ergun KaraagaogluDepartment of Biostatistics, Hacettepe University Medical Faculty, Ankara, Turkey.
Gokcen OrgulDivision of Perinatal Medicine, Department of Obstetrics and Gynecology, Hacettepe University Medical Faculty, Ankara, Turkey.
Fatma GumrukDivision of Hematology Department of Pediatrics, Hacettepe University Medical Faculty, Ankara, Turkey.
Murat YurdakökDivision of Neonatology, Department of Pediatrics, Hacettepe University Medical Faculty, Ankara, Turkey.
M Sinan BeksacDivision of Perinatal Medicine, Department of Obstetrics and Gynecology, Hacettepe University Medical Faculty, Ankara, Turkey.
Hacettepe University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeVanished twin (VT) has been associated with poor perinatal outcomes. Our research aimed to investigate the outcomes of pregnancies with vanished twin and its possible association with methylenetetrahydrofolate reductase (MTHFR) polymorphisms.

methodsThis study consisted of 30 of 38 VT pregnancies (group 1, VT group), 109 singletons (group 2), 70 spontaneous twins (group 3), and 101 in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) twins (group 4).

resultsMost patients in group 1 (28/30) were tested for MTHFR genes (C677T or A1298C polymorphisms). Eight of the 38 pregnancies with VT (21.1%) resulted in miscarriage. The prevalence of "2 or more pregnancy losses" in the "obstetric history" in group 1 was higher (23.3%) than those in the other groups (p = 0.007, χ

conclusionThe coincidence of VT and MTHFR polymorphisms might play an incidental or factual role in this connection.

Indexed as

Genetic Association StudiesAbortion, SpontaneousAdultFemaleFertilization in VitroGene FrequencyHumansMethylenetetrahydrofolate Reductase (NADPH2)Polymorphism, Single NucleotidePregnancyPregnancy ComplicationsPregnancy OutcomePregnancy, TwinSperm Injections, IntracytoplasmicTwinsMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanMethylenetetrahydrofolate reductase polymorphismMiscarriageMultiple pregnanciesVanished twin

Identifiers

PMID30362058
PMCPMC6289921
OpenAlexW2898606788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.