ArticleJournal of assisted reproduction and genetics2019
Chemotherapy-related damage to ovarian reserve in childhood cancer survivors: interpreting the evidence.
Article in Journal of assisted reproduction and genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Plant-derived extracellular vesicles in diabetic wound healing: mechanisms, therapeutic implications and future perspectives.Journal of materials science. Materials in medicine · 2025Review
- Clinical and self-reported markers of reproductive function in female survivors of childhood Hodgkin lymphoma.Journal of cancer research and clinical oncology · 2023Article
- Live birth in woman with premature ovarian insufficiency and 46, XY karyotype after chemotherapy and bone marrow transplant: a case report.BMC pregnancy and childbirth · 2023Article
- The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors.Current oncology (Toronto, Ont.) · 2022Article
- Reproductive Considerations for Patients with Early-Onset Breast Cancer.Current breast cancer reports · 2022Article
- Evaluation of mitochondria in mouse oocytes following cisplatin exposure.Journal of ovarian research · 2021Article
- Pregnancy, time to pregnancy and obstetric outcomes among female childhood cancer survivors: results of the DCOG LATER-VEVO study.Journal of cancer research and clinical oncology · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Chemotherapy during childhood damages ovarian reserve and can affect future fertility. However, recent large epidemiological studies showed that the detrimental impact on fertility is less severe if women seek for pregnancy at a younger age. To explain this observation, we hypothesize that the detrimental effects of previous chemotherapy on the ovarian reserve may be attenuated in young adults for two main reasons. Firstly, recent evidence showed that the amount of ovarian reserve is not a critical factor for effective natural conceptions. Provided that the residual ovarian reserve allows regular ovulatory cycles, the chances of pregnancy are similar in women with intact or reduced ovarian reserve. Secondly, ovarian reserve depletion appears to be a phenomenon that is inversely related to the residual ovarian reserve rather than to age. From a mathematical perspective, this kind of regulation intrinsically attenuates the effects of an early loss of a significant amount of primordial follicles. In conclusion, the detrimental effects of chemotherapy on natural fertility may be less severe if women with a history of chemotherapy during childhood seek for pregnancy early. This information should be part of the counseling.
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