ArticleEuropean journal of drug metabolism and pharmacokinetics2019
In Vitro Assessment of Potential for CYP-Inhibition-Based Drug-Drug Interaction Between Vonoprazan and Clopidogrel.
Article in European journal of drug metabolism and pharmacokinetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Evaluation of CYP2C19-Mediated Pharmacokinetic Drug Interaction of Tegoprazan, Compared with Vonoprazan or Esomeprazole.Clinical pharmacokinetics · 2023Trial
- Overcoming antibiotic-resistantWorld journal of gastroenterology · 2025Review
- Assessments of CYP‑inhibition‑based drug-drug interaction between vonoprazan and poziotinibPharmaceutical biology · 2023Article
- Vonoprazan: A New Potassium-Competitive Acid Blocker.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2023Review
- Tiered approach to evaluate the CYP3A victim and perpetrator drug-drug interaction potential for vonoprazan using PBPK modeling and clinical data to inform labeling.CPT: pharmacometrics & systems pharmacology · 2023Article
- Article
- Pharmacokinetic interaction between peimine and paeoniflorin in rats and its potential mechanism.Pharmaceutical biology · 2021Article
- Co-Administration of Vonoprazan, Not Tegoprazan, Affects the Pharmacokinetics of Atorvastatin in Healthy Male Subjects.Frontiers in pharmacology · 2021Article
- In Vitro and In Vivo Rat Model Assessments of the Effects of Vonoprazan on the Pharmacokinetics of Venlafaxine.Drug design, development and therapy · 2020Article
- Effects of Voriconazole on the Pharmacokinetics of Vonoprazan in Rats.Drug design, development and therapy · 2020Article
- Cytochrome P450-Based Drug-Drug Interactions of VonoprazanFrontiers in pharmacology · 2020Article
- Inhibitory Effect of Vonoprazan on the Metabolism of [European journal of drug metabolism and pharmacokinetics · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesIt was recently proposed that CYP-mediated drug-drug interactions (DDIs) of vonoprazan with clopidogrel and prasugrel can attenuate the antiplatelet actions of the latter two drugs. Clopidogrel is metabolized to the pharmacologically active metabolite H4 and its isomers by multiple CYPs, including CYP2C19 and CYP3A4. Therefore, to investigate the possibility of CYP-based DDIs, in vitro metabolic inhibition studies using CYP probe substrates or radiolabeled clopidogrel and human liver microsomes (HLMs) were conducted in this work.
methodsReversible inhibition studies focusing on the effects of vonoprazan on CYP marker activities and the formation of the [
resultsIt was found that vonoprazan is not a significant direct inhibitor of any CYP isoforms (IC
conclusionsThe body of evidence shows that the pharmacodynamic DDI reported between vonoprazan and clopidogrel is unlikely to be caused by the inhibition of CYP2B6, CYP2C19, or CYP3A4/5 by vonoprazan.
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