Evidence map›Paper›PMID 30361882›Full record

ArticleCancer immunology, immunotherapy : CII2019

Analysis of tumor-infiltrating CD103 resident memory T-cell content in recurrent laryngeal squamous cell carcinoma.

Jacqueline E Mann, Joshua D Smith, Andrew C Birkeland, Emily Bellile, Paul Swiecicki, Michelle Mierzwa, Steven B Chinn, Andrew G Shuman, Kelly M Malloy, Keith A Casper and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Tumor Hypoxia and CD8Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Prognostic value of CD103Oral oncology · 2022
    Article
  15. Article
  16. Review
  17. Frontiers in immunology · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Jacqueline E MannDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA.
Joshua D SmithDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA.
Andrew C BirkelandDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA.
Emily BellileDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Paul SwiecickiDepartment of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA.
Michelle MierzwaDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Steven B ChinnDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA.
Andrew G ShumanDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA.
Kelly M MalloyDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA.
Keith A CasperDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA.
Scott A McLeanDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA.
Jeffery S MoyerDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA.
Gregory T WolfDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA.
Carol R BradfordDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA.
Mark E PrinceDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA.
Thomas E CareyDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA.
Jonathan B McHughDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Matthew E SpectorDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA. mspector@umich.edu.
J Chad BrennerDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, 1150 E. Medical Center Dr., 9301B MSRB3, Ann Arbor, 48109-0602, MI, USA. chadbren@umich.edu.
University of Michigan–Ann Arbor · USA. Alfred Taubman Health Care Center · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Proteogenomics of Cancer Training ProgramT32CA140044 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAO, ARVIND, SARTOR, MAUREEN AGNES · 2010 to 2024
$3.9M
Dissecting Co-Dependent Pathways in Oral CancersU01DE025184 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRENNER, JOHN CHADWICK, CAREY, THOMAS E. · 2015 to 2018
$3.7M
Advanced Research Training in OtolaryngologyT32DC005356 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CORFAS, GABRIEL · 2002 to 2021
$3.5M
Molecular Mechanisms of Tumor Behavior and Response to Therapy in HPV-positive Oropharyngeal CancerR01CA194536 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAREY, THOMAS E. · 2016 to 2021
$2.8M
Advancing Mechanistic Concepts of FGFR1-Regulated Adaptive PDL1 Expression in HNSCCF31DE027600 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MANN, JACQUELINE · 2017 to 2019
$99k
NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA194536NCI NIH HHS T32 CA140044NIDCD NIH HHS T32 DC005356NIDCR NIH HHS F31 DE027600NIDCR NIH HHS U01 DE025184NIH HHS F31-DE-027600-01NIH HHS P30-CA046592NIH HHS R01-CA194536NIH HHS T32-DC535615NIH HHS U01-DE025184
6 · The paper itself

Abstract

backgroundRecurrent laryngeal squamous cell carcinomas (LSCCs) are associated with poor outcomes, without reliable biomarkers to identify patients who may benefit from adjuvant therapies. Given the emergence of tumor-infiltrating lymphocytes (TIL) as a biomarker in head and neck squamous cell carcinoma, we generated predictive models to understand the utility of CD4

methodsTissue microarrays were constructed from salvage laryngectomy specimens of 183 patients with recurrent/persistent LSCC and independently stained for CD4

resultsHigh tumor CD103

conclusionsAn immune profile driven by CD103

Indexed as

Antigens, CDCarcinoma, Squamous CellCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisease-Free SurvivalFemaleHead and Neck NeoplasmsHumansImmunologic MemoryIntegrin alpha ChainsLymphocytes, Tumor-InfiltratingMaleMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalPrognosisalpha E integrinsAntigens, CDIntegrin alpha ChainsCD103HNSCCLarynxResident memoryT-cell

Identifiers

PMID30361882
PMCPMC6375747
OpenAlexW2898231888

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.