ArticleCognitive, affective & behavioral neuroscience2019
Dynamic causal modeling of the effective connectivity between the cerebrum and cerebellum in social mentalizing across five studies.
Article in Cognitive, affective & behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05781412 (Modulation of the Activity in the Cerebellum With Transcranial Direct Current Stimulation in Autistic Participants), which is not on this map. Cited by 59 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Modulation of the Activity in the Cerebellum With Transcranial Direct Current Stimulation in Autistic Participants
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Mentalizing About Dynamic Social Action Sequences Is Supported by the Cerebellum, Basal Ganglia, and Neocortex: A Meta-Analysis of Activation and Connectivity.Human brain mapping · 2024Pooled it
- The posterior crus II cerebellum is specialized for social mentalizing and emotional self-experiences: a meta-analysis.Social cognitive and affective neuroscience · 2020Pooled it
- Female Cerebellum Seems Sociable; An iTBS Investigation.Cerebellum (London, England) · 2024Trial
- Modulating mental state recognition by anodal tDCS over the cerebellum.Scientific reports · 2022Trial
- Directional Brain Connectivity Changes Induced by Heart Rate Variability Biofeedback: A Spectral Dynamic Causal Modeling Study.Research square · 2026Article
- The cerebro-cerebellar system: Integrative roles in motor control, cognition, and neuropsychiatric disorders.IBRO neuroscience reports · 2026Review
- Lorcaserin modulation of semantic drug cue-elicited effective brain connectivity in persons with cocaine and opioid use disorders.Psychiatry research. Neuroimaging · 2025Article
- Altered effective connectivity of emotion perception and regulation networks during an emotional face perception task in adults with alcohol use disorder.Brain structure & function · 2025Article
- Divergent Neural Mechanisms of Self-Concerned and Prosocial Decision-Making Under High and Low Cognitive Loads.Human brain mapping · 2025Article
- Functional recruitment and connectivity of the cerebellum is associated with the emergence of Theory of Mind in early childhood.Nature communications · 2025Article
- The Cerebellum and Striatum in Reward Processing: Caring About Being Right vs. Caring About Reward.bioRxiv : the preprint server for biology · 2025Article
- Crus control: effective cerebello-cerebral connectivity during social action prediction using dynamic causal modelling.Social cognitive and affective neuroscience · 2025Article
- Contributions of the posterior cerebellum to mentalizing and social functioning: A transdiagnostic investigation.Psychological medicine · 2025Article
- Human cerebellum and social navigation: cerebello-cerebral connectivity using dynamic causal modelling.Social cognitive and affective neuroscience · 2025Article
- Social and emotional learning in the cerebellum.Nature reviews. Neuroscience · 2024Review
- Relationship between central autonomic effective connectivity and heart rate variability: A Resting-state fMRI dynamic causal modeling study.NeuroImage · 2024Article
- Consensus Paper: Cerebellum and Reward.Cerebellum (London, England) · 2024Review
- One step too far: social cerebellum in norm-violating navigation.Social cognitive and affective neuroscience · 2024Article
- Create your own path: social cerebellum in sequence-based self-guided navigation.Social cognitive and affective neuroscience · 2024Article
- Disrupted Resting-State Functional Connectivity and Effective Connectivity of the Nucleus Accumbens in Chronic Low Back Pain: A Cross-Sectional Study.Journal of pain research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this analysis we explored the effective connectivity of the cerebellum with the cerebrum in social mentalizing, across five studies (n = 91) involving abstract and complex forms of mentalizing, such as (a) person and group impression formation, based on behavioral descriptions, and (b) constructing personal counterfactual events. Connectivity was analyzed by applying dynamic causal model analysis, which revealed effective connectivity between the mentalizing areas of the cerebellum and cerebrum. The results revealed a significant pattern of bidirectional (closed-loop) connectivity linking the right posterior cerebellum with bilateral temporo-parietal junction (TPJ), associated with behavior understanding. These connections are consistent with known anatomical data on closed loops between the cerebellum and cerebrum, although contralateral closed loops typically dominate. This analysis improves on an earlier psychophysiological interaction analysis of this dataset, which had failed to reveal such evidence of closed loops. Within the cerebrum, there were connections between the bilateral areas of TPJ, as well as connections between bilateral TPJ and the (ventral and dorsal) medial prefrontal cortex. The discussion centers on the function of cerebro-cerebellar connections in generating internal cerebellar "forward" models, potentially serving the automatic understanding, prediction, and error correction of behavioral sequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.