Evidence map›Paper›PMID 30361853›Full record

ReviewCurrent genetics2019

Condensin action and compaction.

Matthew Robert Paul, Andreas Hochwagen, Sevinç Ercan

Abstract readReview
In one paragraph

Review in Current genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Monitoring the compaction of single DNA molecules inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. A proposed unified interphase nucleus chromosome structure: Preliminary preponderance of evidence.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Article
  16. A proposed unified mitotic chromosome architecture.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Matthew Robert PaulDepartment of Biology, New York University, New York, NY, 10003, USA.
Andreas HochwagenDepartment of Biology, New York University, New York, NY, 10003, USA. andi@nyu.edu.
Sevinç ErcanDepartment of Biology, New York University, New York, NY, 10003, USA. se71@nyu.edu.ORCID http://orcid.org/0000-0001-7297-1648
New York University · USNew York Genome Center · US

Funding

Mechanisms of condensin-mediated gene regulation in C. elegansR35GM130311 · NIGMS · NEW YORK UNIVERSITY · PI Sevinc Ercan · 2019 to 2026
$3.3M
Mechanisms of Chromosome Scale Signal PropagationR01GM111715 · NIGMS · NEW YORK UNIVERSITY · PI HOCHWAGEN, ANDREAS · 2015 to 2022
$2.6M
Mechanisms of X chromosome dosage compensation in C. elegansR01GM107293 · NIGMS · NEW YORK UNIVERSITY · PI ERCAN, SEVINC · 2014 to 2018
$1.5M
Chromosomal control of meiotic double-strand break formationR01GM123035 · NIGMS · NEW YORK UNIVERSITY · PI HOCHWAGEN, ANDREAS · 2018 to 2021
$1.2M
NIGMS NIH HHS R01 GM107293NIGMS NIH HHS R01GM107293NIGMS NIH HHS R01 GM111715NIGMS NIH HHS R01GM111715NIGMS NIH HHS R01 GM123035NIGMS NIH HHS R35 GM130311
6 · The paper itself

Abstract

Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination. Recent research defined the structural features and molecular activities of condensins, but it is unclear how these activities are connected to the multitude of phenotypes and functions attributed to condensins. In this review, we briefly discuss the different molecular mechanisms by which condensins may regulate global chromosome compaction, organization of topologically associated domains, clustering of specific loci such as tRNA genes, rDNA segregation, and gene regulation.

Indexed as

Adenosine TriphosphatasesAnimalsCell DivisionChromatin Assembly and DisassemblyChromosomesDNA-Binding ProteinsDNA, RibosomalGene Expression RegulationGenetic LociGenomeHumansInterphaseMultiprotein ComplexesRNA, TransferTranscription, GeneticAdenosine Triphosphatasescondensin complexesDNA-Binding ProteinsDNA, RibosomalMultiprotein ComplexesRNA, TransferChromosome interactionsChromosome segregationClusteringCondensingene expressionGenome organizationrDNASMC complexesTADsTranscriptiontRNA

Identifiers

PMID30361853
PMCPMC6421088
OpenAlexW2898531321

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.