ArticleClinical & experimental metastasis2018
miR-21 expression analysis in budding colon cancer cells by confocal slide scanning microscopy.
Article in Clinical & experimental metastasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Diagnostic Relevance of miR-185, miR-141, and miR-21 in Colon Carcinoma: Insights into Tumor Sidedness and Reference Gene Selection.Biomedicines · 2025Article
- Molecular roles of microRNA-21 and exosomal miR-21 in gastrointestinal cancers: diagnostic, therapeutic, and drug resistance insights.Frontiers in molecular biosciences · 2025Review
- Architectural organization and molecular profiling of 3D cancer heterospheroids and their application in drug testing.Frontiers in oncology · 2024Article
- Tumor budding as a potential prognostic marker in determining the behavior of primary liver cancers.World journal of hepatology · 2023Review
- Circ-LocNet: A Computational Framework for Circular RNA Sub-Cellular Localization Prediction.International journal of molecular sciences · 2022Article
- Monocyte Infiltration and Differentiation in 3D Multicellular Spheroid Cancer Models.Pathogens (Basel, Switzerland) · 2021Article
- Article
- Tumour budding in solid cancers.Nature reviews. Clinical oncology · 2021Review
- Detection of lncRNA by LNA-Based In Situ Hybridization in Paraffin-Embedded Cancer Cell Spheroids.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Co-Detection of miR-21 and TNF-α mRNA in Budding Cancer Cells in Colorectal Cancer.International journal of molecular sciences · 2019Article
- Downregulated miR-585-3p promotes cell growth and proliferation in colon cancer by upregulatingOncoTargets and therapy · 2019Article
- miR-21: a promising biomarker for the early detection of colon cancer.OncoTargets and therapy · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNA-21 (miR-21) expression in stromal fibroblastic cells in colorectal cancer is well-documented, whereas miR-21 expression in tumor budding cells (TBCs) is poorly described. TBCs are locally invasive carcinoma cells with increased metastatic properties and characteristics of epithelial to mesenchymal transition. This study was conducted to better characterize the expression of miR-21 in TBCs. First, chromogenic miR-21 in situ hybridization (ISH) staining was performed in 58 colon adenocarcinomas with evident TBCs. Then, to obtain unambiguous identification of miR-21 in the TBCs, twenty cases were selected for an additional multiplex fluorescence analysis combining miR-21 ISH with cytokeratin and laminin-5γ2 immunofluorescence. Employing confocal slide scanning microscopy, comprehensive digital images of the invasive front (10-40 mm
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