ArticleScientific reports2018
Computational Simulations of Thrombolytic Therapy in Acute Ischaemic Stroke.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Numerical investigation of ultrasound-induced acoustic streaming and shear stress for blood clot manipulation.Scientific reports · 2026Article
- Comparative study on efficacy of thrombolytic protocols: Dual therapy against standard tPA regimen.Biophysical journal · 2025Article
- A mathematical model of plasmin-mediated fibrinolysis of single fibrin fibers.PLoS computational biology · 2024Article
- Decoding thrombosis through code: a review of computational models.Journal of thrombosis and haemostasis : JTH · 2024Review
- A simplified mesoscale 3D model for characterizing fibrinolysis under flow conditions.Scientific reports · 2023Article
- In Silico Study of Different Thrombolytic Agents for Fibrinolysis in Acute Ischemic Stroke.Pharmaceutics · 2023Article
- Effects of clot contraction on clot degradation: A mathematical and experimental approach.Biophysical journal · 2022Article
- Multiphysics Modelling and Simulation of Thrombolysis via Activated Platelet-Targeted Nanomedicine.Pharmaceutical research · 2022Article
- The Utility and Potential of Mathematical Models in Predicting Fibrinolytic Outcomes.Current opinion in biomedical engineering · 2021Article
- Modelling Combined Intravenous Thrombolysis and Mechanical Thrombectomy in Acute Ischaemic Stroke: Understanding the Relationship between Stent Retriever Configuration and Clot Lysis Mechanisms.Life (Basel, Switzerland) · 2021Article
- Investigating the two regimes of fibrin clot lysis: an experimental and computational approach.Biophysical journal · 2021Article
- Fibrinogen-mimicking, multiarm nanovesicles for human thrombus-specific delivery of tissue plasminogen activator and targeted thrombolytic therapy.Science advances · 2021Article
- Article
- Redistribution of TPA Fluxes in the Presence of PAI-1 Regulates Spatial Thrombolysis.Biophysical journal · 2020Article
- Endothelial Cell Activation in an Embolic Ischemia-Reperfusion Injury Microfluidic Model.Micromachines · 2019Article
- Mathematical Modelling of Intravenous Thrombolysis in Acute Ischaemic stroke: Effects of Dose Regimens on Levels of Fibrinolytic Proteins and Clot Lysis Time.Pharmaceutics · 2019Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischaemic stroke can occur when an artery to the brain is blocked by a blood clot. The use of thrombolytic agents, such as tissue plasminogen activator (tPA), to dissolve the occluding clot is limited by the risk of intracerebral haemorrhage (ICH), a known side effect associated with tPA. We developed a computational thrombolysis model for a 3D patient-specific artery coupled with a compartmental model for temporal concentrations of tPA and lysis proteins during intravenous infusion of tPA, in order to evaluate the effects of tPA dose on the efficacy of thrombolytic therapy and the risk of ICH. The model was applied to a 3-mm-long fibrin clot with two different fibrin fibre radii in the middle cerebral artery (MCA) - a setting relevant to ischaemic stroke, and results for different tPA dose levels and fibrin fibre radii were compared. Our simulation results showed that clot lysis was accelerated at higher tPA doses at the expense of a substantial increase in the risk of ICH. It was also found that a fine clot with a smaller fibre radius dissolved much slowly than a coarse clot due to a slower tPA penetration into the clots.
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