ArticleNature communications2018
Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Arf1 is involved in Neisseria meningitidis-induced cortical branched F-actin network reorganization.EMBO reports · 2026Article
- An in vitro human vessel model to studyeLife · 2025Article
- Meningococci drive host membrane tubulation to recruit their signaling receptors.Nature communications · 2025Article
- Nanofibrous dressings incorporating a synergistic antibacterial-anti-inflammatory effect for infected wound healing.Materials today. Bio · 2025Article
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- Dynamics of Endothelial Engagement and Filopodia Formation in Complex 3D Microscaffolds.International journal of molecular sciences · 2022Article
- Imaging Infection Across Scales of Size: From Whole Animals to Single Molecules.Annual review of microbiology · 2021Review
- Article
- Mechanisms of Motor-Independent Membrane Remodeling Driven by Dynamic Microtubules.Current biology : CB · 2020Article
- Biological lipid nanotubes and their potential role in evolution.The European physical journal. Special topics · 2020Review
- Deep mutational scanning of the Neisseria meningitidis major pilin reveals the importance of pilus tip-mediated adhesion.The EMBO journal · 2019Article
- Molecular interactions between Neisseria meningitidis and its human host.Cellular microbiology · 2019Review
- The best of both worlds-bringing together cell biology and infection at the Institut Pasteur.Genes and immunity · 2019Review
- The Many Faces of Bacterium-Endothelium Interactions during Systemic Infections.Microbiology spectrum · 2019Review
- Astrocytes in Flavivirus Infections.International journal of molecular sciences · 2019Review
- Nanofibres induce remodelling of cell membranes.Nature · 2018Article
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Authors and funding
19 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The shape of cellular membranes is highly regulated by a set of conserved mechanisms that can be manipulated by bacterial pathogens to infect cells. Remodeling of the plasma membrane of endothelial cells by the bacterium Neisseria meningitidis is thought to be essential during the blood phase of meningococcal infection, but the underlying mechanisms are unclear. Here we show that plasma membrane remodeling occurs independently of F-actin, along meningococcal type IV pili fibers, by a physical mechanism that we term 'one-dimensional' membrane wetting. We provide a theoretical model that describes the physical basis of one-dimensional wetting and show that this mechanism occurs in model membranes interacting with nanofibers, and in human cells interacting with extracellular matrix meshworks. We propose one-dimensional wetting as a new general principle driving the interaction of cells with their environment at the nanoscale that is diverted by meningococci during infection.
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