ArticleScientific reports2018
Dental pulp-derived stem cells can counterbalance peripheral nerve injury-induced oxidative stress and supraspinal neuro-inflammation in rat brain.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Stepwise Regulation of Cellular Oxidative Stress via Conductive-Piezoelectric Integrated Microstructured Conduits for Enhanced Nerve Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Sodium Nitrate Combined With Dental Pulp Stem Cells Alleviates Atherosclerosis Through Inhibiting Oxidative Stress.Stem cells international · 2026Article
- Fabrication of GDNF-Gel/HA-Mg nerve conduit and its role in repairing peripheral nerve defects.Materials today. Bio · 2025Article
- The Application of Stem Cells and Exosomes in Promoting Nerve Conduits for Peripheral Nerve Repair.Biomaterials research · 2025Review
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- Potential of dental pulp stem cells and their products in promoting peripheral nerve regeneration and their future applications.World journal of stem cells · 2023Review
- VEGFA-modified DPSCs combined with LC-YE-PLGA NGCs promote facial nerve injury repair in rats.Heliyon · 2023Article
- Application of Dental Pulp Stem Cells for Bone and Neural Tissue Regeneration in Oral and Maxillofacial Region.Stem cells international · 2023Review
- Anti-inflammatory effect of dental pulp stem cells.Frontiers in immunology · 2023Review
- Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord.Molecular pain · 2022Article
- Immunomodulatory effects of mesenchymal stem cells in peripheral nerve injury.Stem cell research & therapy · 2022Review
- TAZ Induces Migration of Microglia and Promotes Neurological Recovery After Spinal Cord Injury.Frontiers in pharmacology · 2022Article
- Human dental pulp stem cells attenuate streptozotocin-induced parotid gland injury in rats.Stem cell research & therapy · 2021Article
- The influence of reduced graphene oxide on stem cells: a perspective in peripheral nerve regeneration.Regenerative biomaterials · 2021Review
- Silencing VEGFR-2 Hampers Odontoblastic Differentiation of Dental Pulp Stem Cells.Frontiers in cell and developmental biology · 2021Article
- Effects of Resistance Training andAntioxidants (Basel, Switzerland) · 2020Article
- Epigenetic Regulation of Dental Pulp Stem Cell Fate.Stem cells international · 2020Review
- Hydroxysafflor Yellow A Exerts Anti-Inflammatory Effects Mediated by SIRT1 in Lipopolysaccharide-Induced Microglia Activation.Frontiers in pharmacology · 2020Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously, we reported the successful regeneration of injured peripheral nerves using human dental pulp stem cells (DPSCs) or differentiated neuronal cells from DPSCs (DF-DPSCs) in a rat model. Here, we attempted to evaluate oxidative stress and supraspinal neuro-inflammation in rat brain after sciatic nerve injury (SNI). We divided our experimental animals into three SNI groups based on time. The expression of a microglial (Iba1) marker and reactive oxygen species (ROS) was lower in DPSCs and higher in DF-DPSCs. In contrast, the expression of an astroglial (GFAP) marker was higher in DPSCs and lower in DF-DPSCs at 2 weeks. However, the expression of ROS, Iba1 and GFAP gradually decreased at 8 and 12 weeks in the SNI DPSCs and DF-DPSCs groups compared to the SNI control. Furthermore, anti-inflammatory cytokine (IL-4 and TGF-β) expression was lower at 2 weeks, while it gradually increased at 8 and 12 weeks after surgery in the SNI DPSCs and DF-DPSCs groups. Similarly, SNI DPSCs had a high expression of pAMPK, SIRT1 and NFkB at the onset of SNI. However, 12 weeks after surgery, pAMPK and SIRT1 expression levels were higher and NFkB was down-regulated in both DPSCs and DF-DPSCs compared to the control group. Finally, we concluded that DPSCs responded early and more efficiently than DF-DPSCs to counterbalance peripheral nerve injury (PNI)-induced oxidative stress and supraspinal neuro-inflammation in rat brain.
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