Evidence map›Paper›PMID 30361627›Full record

ArticleNature communications2018

Medial temporal lobe functional connectivity predicts stimulation-induced theta power.

E A Solomon, J E Kragel, R Gross, B Lega, M R Sperling, G Worrell, S A Sheth, K A Zaghloul, B C Jobst, J M Stein and 6 more

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  7. Quantum-inspired entanglement between collaborating brains during human memory encoding.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Article
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  11. Synchronous Theta Networks Characterize Successful Memory Retrieval.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

E A SolomonDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19146, USA. esolo@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-0541-7588
J E KragelDepartment of Psychology, University of Pennsylvania, Philadelphia, PA, 19146, USA.
R GrossDepartment of Neurosurgery, Emory School of Medicine, Atlanta, GA, 30322, USA.
B LegaDepartment of Neurosurgery, University of Texas Southwestern, Dallas, TX, 75390, USA.
M R SperlingDepartment of Neurology, Thomas Jefferson University Hospital, Philadelphia, PA, 19107, USA.
G WorrellDepartment of Neurology, Department of Physiology and Bioengineering, Mayo Clinic, Rochester, MN, 55905, USA.
S A ShethDepartment of Neurosurgery, Baylor College of Medicine, Houston, TX, 77030, USA.
K A ZaghloulSurgical Neurology Branch, National Institutes of Health, Bethesda, MD, 20814, USA.ORCID http://orcid.org/0000-0001-8575-3578
B C JobstDepartment of Neurology, Dartmouth Medical Center, Lebanon, NH, 03756, USA.
J M SteinDepartment of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA.
S DasDepartment of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA.
R GorniakDepartment of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, 19107, USA.
C S InmanDepartment of Neurosurgery, Emory School of Medicine, Atlanta, GA, 30322, USA.
S SegerDepartment of Neurosurgery, University of Texas Southwestern, Dallas, TX, 75390, USA.
D S RizzutoDepartment of Psychology, University of Pennsylvania, Philadelphia, PA, 19146, USA.
M J KahanaDepartment of Psychology, University of Pennsylvania, Philadelphia, PA, 19146, USA. kahana@psych.upenn.edu.

Funding

Investigating the neural mechanisms of human cognitive function through intracranial recordingsZIANS003144 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ZAGHLOUL, KAREEM · 2014 to 2025
$36.1M
Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Associative Processes in Episodic MemoryR01MH055687 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI KAHANA, MICHAEL JACOB · 2002 to 2024
$7.9M
Training Program in Neuroengineering and MedicineT32NS091006 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Brian Litt · 2015 to 2026
$4.1M
Virtual Resection to Treat EpilepsyR01NS099348 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH, LITT, BRIAN · 2016 to 2019
$2.3M
Associative Processes in Episodic MemoryRF1MH055687 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI KAHANA, MICHAEL JACOB · 2025 to 2025
$1.1M
MATHEMATICAL MODELS OF HUMAN MEMORYR29MH055687 · NIMH · BRANDEIS UNIVERSITY · PI KAHANA, MICHAEL JACOB · 1997 to 2001
$218k
NIMH NIH HHS R01 MH055687NIMH NIH HHS R29 MH055687NIMH NIH HHS RF1 MH055687NIMH NIH HHS U54 MH091657NINDS NIH HHS R01 NS099348NINDS NIH HHS T32 NS091006
6 · The paper itself

Abstract

Focal electrical stimulation of the brain incites a cascade of neural activity that propagates from the stimulated region to both nearby and remote areas, offering the potential to control the activity of brain networks. Understanding how exogenous electrical signals perturb such networks in humans is key to its clinical translation. To investigate this, we applied electrical stimulation to subregions of the medial temporal lobe in 26 neurosurgical patients fitted with indwelling electrodes. Networks of low-frequency (5-13 Hz) spectral coherence predicted stimulation-evoked increases in theta (5-8 Hz) power, particularly when stimulation was applied in or adjacent to white matter. Stimulation tended to decrease power in the high-frequency broadband (HFB; 50-200 Hz) range, and these modulations were correlated with HFB-based networks in a subset of subjects. Our results demonstrate that functional connectivity is predictive of causal changes in the brain, capturing evoked activity across brain regions and frequency bands.

Indexed as

Electric StimulationEvoked PotentialsHumansNerve NetTemporal LobeTheta RhythmWhite Matter

Identifiers

PMID30361627
PMCPMC6202342

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.