ArticleNature communications2018
Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation.
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Animal models of chronic graft-versus-host disease with oral involvement: A review.European journal of oral sciences · 2026Review
- Smac mimetic combined with eCD4-Ig reverses latency without reducing SHIV reservoirs in rhesus macaques.The Journal of clinical investigation · 2026Article
- Lactylation of METTL16 promotes cuproptosis via mNature communications · 2023Article
- Efficient manufacturing and engraftment ofMolecular therapy. Methods & clinical development · 2023Article
- Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques.Immunity · 2023Article
- EfficientFrontiers in immunology · 2023Article
- Applying a clinical lens to animal models of CAR-T cell therapies.Molecular therapy. Methods & clinical development · 2022Review
- Animal models for studies of HIV-1 brain reservoirs.Journal of leukocyte biology · 2022Review
- Allogeneic MHC-matched T-cell receptor α/β-depleted bone marrow transplants in SHIV-infected, ART-suppressed Mauritian cynomolgus macaques.Scientific reports · 2022Article
- Genome editing in large animal models.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Review
- Identification and Tracking of Alloreactive T Cell Clones in Rhesus Macaques Through the RM-scTCR-Seq Platform.Frontiers in immunology · 2021Article
- Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates.Blood · 2020Article
- Isolation of a Highly Purified HSC-enriched CD34Transplantation direct · 2020Article
- The Brain Retains: Nonhuman Primate Models for Pediatric HIV-1 in the CNS.Current HIV/AIDS reports · 2020Review
- Article
Corrections and comments
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Authors and funding
39 authors at 5 institutions in 1 country.
Lucrezia ColonnaBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Suite 100, Seattle, WA, 98101, USA.
Christopher W PetersonStem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, 98109, WA, USA.
John B SchellBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Suite 100, Seattle, WA, 98101, USA.ORCID http://orcid.org/0000-0001-6707-7051
Judith M CarlsonBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Suite 100, Seattle, WA, 98101, USA.
Victor TkachevBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Suite 100, Seattle, WA, 98101, USA.ORCID http://orcid.org/0000-0001-6011-0576
Melanie BrownBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Suite 100, Seattle, WA, 98101, USA.
Alison YuBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Suite 100, Seattle, WA, 98101, USA.
Sowmya ReddyStem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, 98109, WA, USA.
Willi M ObenzaStem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, 98109, WA, USA.
Veronica NelsonStem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, 98109, WA, USA.
Patricia S PolacinoWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Heather MackWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Shiu-Lok HuWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Katie ZeleskiBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Suite 100, Seattle, WA, 98101, USA.
Michelle HoffmanBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Suite 100, Seattle, WA, 98101, USA.
Joe OlveraWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Scott N FurlanBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Suite 100, Seattle, WA, 98101, USA.
Hengqi ZhengBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Suite 100, Seattle, WA, 98101, USA.ORCID http://orcid.org/0000-0003-0575-6475
Agne TaraseviciuteBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Suite 100, Seattle, WA, 98101, USA.
Daniel J HuntBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Suite 100, Seattle, WA, 98101, USA.
Kayla BetzBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Suite 100, Seattle, WA, 98101, USA.
Jennifer F LaneWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Keith VogelWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Charlotte E HotchkissWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Cassie MoatsWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Audrey BaldessariWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Robert D MurnaneWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Christopher EnglishWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Cliff A AstleyWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Solomon WangariWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Brian AgricolaWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Joel AhrensWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Naoto IwayamaWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Andrew MayWashington National Primate Research Center, 1705 NE Pacific Street, Box 357330, Seattle, WA, 98195, USA.
Laurence StenslandDepartment of Laboratory Medicine, University of Washington, Box 357110, 1959 NE Pacific Street, Seattle, WA, 98195-7110, USA.
Meei-Li W HuangDepartment of Laboratory Medicine, University of Washington, Box 357110, 1959 NE Pacific Street, Seattle, WA, 98195-7110, USA.
Keith R JeromeDepartment of Laboratory Medicine, University of Washington, Box 357110, 1959 NE Pacific Street, Seattle, WA, 98195-7110, USA.
Hans-Peter KiemStem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, 98109, WA, USA.ORCID http://orcid.org/0000-0001-5949-4947
Leslie S KeanBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Suite 100, Seattle, WA, 98101, USA. leslie.kean@childrens.harvard.edu.
Seattle Children's Hospital · USUniversity of Washington · USFred Hutch Cancer Center · USSeattle Pacific University · USMontana State University · US
Funding
Transplant Tolerance in Non-Human PrimatesU19AI051731 · NIAID · UNIVERSITY OF WESTERN ONTARIO · PI LARSEN, CHRISTIAN P. · 2002 to 2022
$54.1MHarvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4MBELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral EradicationUM1AI126617 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JONES, R. BRAD, NIXON, DOUGLAS F · 2016 to 2020
$28.1MCell and Gene Therapy for HIV CureUM1AI126623 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI JEROME, KEITH R, KIEM, HANS-PETER · 2016 to 2020
$24.2MZFN-Modified Stem Cells for HIV EradicationU19AI096111 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KIEM, HANS-PETER · 2011 to 2015
$20.8MNovel Biologic Therapies for GVHDR01HL095791 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI KEAN, LESLIE S · 2010 to 2025
$13.3MStem cell expansion and gene editing in a nonhuman primate model of HIV/AIDSU19HL129902 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KIEM, HANS-PETER · 2015 to 2019
$12.8MEngraftment and in vivo selection of HIV-protected stem cellsR01HL116217 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KIEM, HANS-PETER · 2012 to 2017
$3.8MCuring HIV Through Allogeneic Hematopoietic Stem Cell Transplantation -- (KEAN)R33AI116184 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI KEAN, LESLIE S · 2016 to 2018
$1.6MCuring HIV Through Allogeneic Hematopoietic Stem Cell TransplantationR21AI116184 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI KEAN, LESLIE S · 2014 to 2015
$584kNCATS NIH HHS UL1 TR000170NHLBI NIH HHS R01 HL095791NHLBI NIH HHS R01 HL116217NHLBI NIH HHS U19 HL129902NIAID NIH HHS R21 AI116184NIAID NIH HHS R33 AI116184NIAID NIH HHS U19 AI051731NIAID NIH HHS U19 AI096111NIAID NIH HHS UM1 AI126617NIAID NIH HHS UM1 AI126623U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI116184
Abstract
Allogeneic transplantation (allo-HCT) has led to the cure of HIV in one individual, raising the question of whether transplantation can eradicate the HIV reservoir. To test this, we here present a model of allo-HCT in SHIV-infected, cART-suppressed nonhuman primates. We infect rhesus macaques with SHIV-1157ipd3N4, suppress them with cART, then transplant them using MHC-haploidentical allogeneic donors during continuous cART. Transplant results in ~100% myeloid donor chimerism, and up to 100% T-cell chimerism. Between 9 and 47 days post-transplant, terminal analysis shows that while cell-associated SHIV DNA levels are reduced in the blood and in lymphoid organs post-transplant, the SHIV reservoir persists in multiple organs, including the brain. Sorting of donor-vs.-recipient cells reveals that this reservoir resides in recipient cells. Moreover, tetramer analysis indicates a lack of virus-specific donor immunity post-transplant during continuous cART. These results suggest that early post-transplant, allo-HCT is insufficient for recipient reservoir eradication despite high-level donor chimerism and GVHD.
Indexed as
Hematopoietic Stem Cell TransplantationMajor Histocompatibility ComplexTransplantation, HaploidenticalAnimalsAntiretroviral Therapy, Highly ActiveCD8-Positive T-LymphocytesDisease ReservoirsDNA, ViralMacaca mulattaRNA, ViralSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusTransplantation, HomologousDNA, ViralRNA, Viral
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