Evidence map›Paper›PMID 30361504›Full record

ArticleCell death & disease2018

circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma.

Xiao Zhang, Yanfeng Xu, Zijun Qian, Weisheng Zheng, Qi Wu, Yan Chen, Guoqing Zhu, Ya Liu, Zhixuan Bian, Wen Xu and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 2 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 2 syntheses or guidelines pooled it, 254 citations in OpenAlex.

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  11. Exploring the methyl-verse: Dynamic interplay of epigenome and m6A epitranscriptome.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Xiao ZhangDepartment of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, 200072, Shanghai, China.
Yanfeng XuDepartment of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 200071, Shanghai, China.
Zijun QianShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 200071, Shanghai, China.
Weisheng ZhengSchool of Life Science and Technology, Shanghai Key Laboratory of Signaling and Disease Research, Tongji University, 200092, Shanghai, China.
Qi WuDepartment of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, 200072, Shanghai, China.
Yan ChenDepartment of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, 200072, Shanghai, China.
Guoqing ZhuDepartment of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, 200072, Shanghai, China.
Ya LiuDepartment of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, 200072, Shanghai, China.
Zhixuan BianDepartment of Laboratory Medicine, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, 200127, Shanghai, China.
Wen XuDepartment of Laboratory Medicine, Zhongshan Hospital, Fudan University, 200025, Shanghai, China.
Yue ZhangDepartment of Central Laboratory, Shanghai Tenth People's Hospital of Tongji University, 200072, Shanghai, China.
Fenyong SunDepartment of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, 200072, Shanghai, China.
Qiuhui PanDepartment of Laboratory Medicine, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, 200127, Shanghai, China.
Jiayi WangDepartment of Clinical Laboratory Medicine, Shanghai Tenth People's Hospital of Tongji University, 200072, Shanghai, China. karajan2@163.com.
Lutao DuDepartment of Clinical Laboratory, The Second Hospital of Shandong University, 250033, Jinan, Shandong, China. lutaodu@sdu.edu.cn.
Yongchun YuShanghai Chest Hospital, Shanghai Jiao Tong University, 200030, Shanghai, China. yyc2166@sjtu.edu.cn.
Shanghai Tenth People's Hospital · CNTongji University · CNShanghai Children's Medical Center · CNShanghai University of Traditional Chinese Medicine · CNSecond Hospital of Shandong University · CNShanghai Jiao Tong University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some types of circular RNA (circRNA) are aberrantly expressed in human diseases including hepatocellular carcinoma (HCC). However, its regulation mechanism and diagnostic roles are largely unknown. Here, we identified that circRNA_104075 (circ_104075) was highly expressed in HCC tissues, cell lines and serum. Mechanistically, HNF4a bound to the -1409 to -1401 region of the circ_104075 promoter to stimulate the expression of circ_104075. Moreover, circ_104075 acted as a ceRNA to upregulate YAP expression by absorbing miR-582-3p. Interestingly, an N

Indexed as

Adaptor Proteins, Signal TransducingAdenosineAdultAgedAnimalsBiomarkers, TumorCarcinogenesisCarcinoma, HepatocellularCell SurvivalFemaleHepatocyte Nuclear Factor 4Hep G2 CellsHumansLiver NeoplasmsMaleMiceAdaptor Proteins, Signal TransducingAdenosineBiomarkers, TumorHepatocyte Nuclear Factor 4HNF4A protein, humanHnf4a protein, mouseMicroRNAsMIRN582 microRNA, humanN-methyladenosineRNA, CircularTranscription FactorsYAP1 protein, humanYAP-Signaling Proteins

Identifiers

PMID30361504
PMCPMC6202383
OpenAlexW2898404896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.