Evidence map›Paper›PMID 30361440›Full record

ArticleThe Journal of biological chemistry2018

Thermodynamic constraints on the regulation of metabolic fluxes.

Ziwei Dai, Jason W Locasale

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. NMR-Based Stable Isotope Tracing of Cancer Metabolism.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  6. Article
  7. Article
  8. HyperpolarizedMolecules (Basel, Switzerland) · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ziwei DaiFrom the Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina 27710 ziwei.dai@duke.edu.ORCID 0000-0002-0858-638X
Jason W LocasaleFrom the Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina 27710 jason.locasale@duke.edu.ORCID 0000-0002-7766-3502
Duke University · US

Funding

Dietary methionine and cancerR01CA193256 · NCI · DUKE UNIVERSITY · PI LOCASALE, JASON W. · 2015 to 2023
$3.1M
Understanding metabolic flux and the control of mammalian cell growthR00CA168997 · NCI · DUKE UNIVERSITY · PI LOCASALE, JASON W. · 2013 to 2015
$695k
NCI NIH HHS R00 CA168997NCI NIH HHS R01 CA193256
6 · The paper itself

Abstract

Nutrition and metabolism are fundamental to cellular function. Metabolic activity (

Indexed as

Metabolic Networks and PathwaysModels, BiologicalGlycolysisKineticsThermodynamicscomputational biologyenzyme kineticsmetabolic control analysismetabolic regulationmetabolismthermodynamics

Identifiers

PMID30361440
PMCPMC6314121
OpenAlexW2951652083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.