Evidence map›Paper›PMID 30361436›Full record

ArticleThe Journal of biological chemistry2018

Red wine and green tea flavonoids are

Ogooluwa A Ojelabi, Kenneth P Lloyd, Julie K De Zutter, Anthony Carruthers

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

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  14. Erythroid glucose transport in health and disease.Pflugers Archiv : European journal of physiology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ogooluwa A OjelabiFrom the Department of Biochemistry and Molecular Pharmacology, Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Kenneth P LloydFrom the Department of Biochemistry and Molecular Pharmacology, Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Julie K De ZutterFrom the Department of Biochemistry and Molecular Pharmacology, Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, Massachusetts 01605.
Anthony CarruthersFrom the Department of Biochemistry and Molecular Pharmacology, Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, Massachusetts 01605 anthony.carruthers@umassmed.edu.
University of Massachusetts Chan Medical School · US

Funding

SUGAR TRANSPORTER OLIGOMERIC STRUCTURE AND FUNCTIONR01DK044888 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CARRUTHERS, ANTHONY · 1992 to 2016
$4.2M
METABOLIC CONTROL OF SUGAR TRANSPORTR01DK036081 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CARRUTHERS, ANTHONY · 1986 to 2012
$3.4M
Metabolic control of sugar transportR56DK036081 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CARRUTHERS, ANTHONY · 2007 to 2007
$266k
NIDDK NIH HHS R01 DK036081NIDDK NIH HHS R01 DK044888NIDDK NIH HHS R56 DK036081
6 · The paper itself

Abstract

The antioxidant- and flavonoid-rich contents of red wine and green tea are reported to offer protection against cancer, cardiovascular disease, and diabetes. Some studies, however, show that flavonoids inhibit GLUT1-mediated, facilitative glucose transport, raising the possibility that their interaction with GLUT1 and subsequent downstream effects on carbohydrate metabolism may also impact health. The present study explores the structure-function relationships of flavonoid-GLUT1 interactions. We find that low concentrations of flavonoids act as

Indexed as

Allosteric RegulationBinding, CompetitiveBiological TransportFlavonoidsGlucose Transporter Type 1HEK293 CellsHumansInsulinMolecular Docking SimulationProtein ConformationSugarsTeaWineFlavonoidsGlucose Transporter Type 1InsulinSugarsTeaallosteric regulationglucose transportmembrane transportoligomerizationstructure-function

Identifiers

PMID30361436
PMCPMC6314135
OpenAlexW2909575447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.