Evidence map›Paper›PMID 30361434›Full record

ArticleAJNR. American journal of neuroradiology2018

Hemodynamic Impairment Measured by Positron-Emission Tomography Is Regionally Associated with Decreased Cortical Thickness in Moyamoya Phenomenon.

J J Lee, J S Shimony, H Jafri, A R Zazulia, R G Dacey, G R Zipfel, C P Derdeyn

Open access · hybridAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Atrophy in subcortical gray matter in adult patients with moyamoya disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  4. Structural abnormalities in paediatric moyamoya disease revealed by clinical magnetic resonance imaging, regionally distributed relative signal intensities and volumes.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2022
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

J J LeeFrom the Mallinckrodt Institute of Radiology (J.J.L., J.S.S., H.J., A.R.Z.) jjlee@wustl.edu.ORCID 0000-0003-2269-6267
J S ShimonyFrom the Mallinckrodt Institute of Radiology (J.J.L., J.S.S., H.J., A.R.Z.).ORCID 0000-0002-6228-776X
H JafriFrom the Mallinckrodt Institute of Radiology (J.J.L., J.S.S., H.J., A.R.Z.).ORCID 0000-0001-5102-1328
A R ZazuliaFrom the Mallinckrodt Institute of Radiology (J.J.L., J.S.S., H.J., A.R.Z.).ORCID 0000-0002-6956-5603
R G DaceyNeurosurgery (R.G.D., G.R.Z.), Washington University, St Louis, Missouri.ORCID 0000-0002-9181-6413
G R ZipfelDepartments of Neurology (A.R.Z., G.R.Z.).ORCID 0000-0003-2737-9084
C P DerdeynDepartment of Radiology (C.P.D.), University of Iowa, Iowa City, Iowa.ORCID 0000-0002-5932-2683
Research Institute of Radiology · BYWashington University in St. Louis · USUniversity of Iowa · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
Washington University Institute of Clinical and Translational Sciences (KL2)KL2RR024994 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$8.6M
proj 3 - NINDS INSTIUTIONAL CENTER CORE GRANTS TO SUPPORT NEUROSCIENCE RESEARP30NS048056 · NINDS · WASHINGTON UNIVERSITY · PI MINTUN, MARK A. · 2004 to 2014
$7.4M
Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI CONSTANTINO, JOHN N. · 2015 to 2019
$7.1M
Washington University Institute of Clinical and Translational Sciences (TL1)TL1RR024995 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$2.3M
The Role of Cerebral Hemodynamics in Moya Moya DiseaseR01NS051631 · NINDS · WASHINGTON UNIVERSITY · PI DERDEYN, COLIN PIETER · 2006 to 2010
$1.6M
NCATS NIH HHS UL1 TR002345NCRR NIH HHS KL2 RR024994NCRR NIH HHS TL1 RR024995NCRR NIH HHS UL1 RR024992NICHD NIH HHS U54 HD087011NINDS NIH HHS P30 NS048056NINDS NIH HHS R01 NS051631
6 · The paper itself

Abstract

background and purposeImpaired cerebrovascular reactivity has been associated with decreased cortical thickness in patients with arterial occlusive diseases. This study tests the hypothesis that severe hemodynamic impairment, indicated by increased oxygen extraction fraction ratios on positron-emission tomography with MATERIALS AND

methodsPatients with unilateral or bilateral idiopathic Moyamoya phenomenon were recruited. Oxygen extraction fraction ratio maps were generated from cerebral images of O[

resultsComplete MR imaging and PET datasets were available in 35 subjects, including 23 women; the mean age at scanning was 44 years. Patients with Moyamoya phenomenon had a significantly increased regional oxygen extraction fraction ratio compared with 15 healthy control subjects (

conclusionsChronic hemodynamic impairment, as indicated by a higher regional oxygen extraction fraction ratio, was significantly predictive of reduced cortical thickness in mixed-effects analysis of FreeSurfer regions. This phenomenon may be related to reversible metabolic down-regulation.

Indexed as

AdultCerebral CortexCerebrovascular CirculationFemaleHemodynamicsHumansMagnetic Resonance ImagingMaleMiddle AgedMoyamoya DiseasePositron-Emission Tomography

Identifiers

PMID30361434
PMCPMC7655355
OpenAlexW2898576739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.