Evidence map›Paper›PMID 30361393›Full record

ArticleEMBO reports2018

ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity.

Taisuke Nakahama, Yuki Kato, Jung In Kim, Tuangtong Vongpipatana, Yutaka Suzuki, Carl R Walkley, Yukio Kawahara

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Two codes of RNA editing by deamination in human diseases.Experimental & molecular medicine · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Sterile production of interferons in the thymus.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
  7. The role of ADAR1 in human pathophysiology.Frontiers in cell and developmental biology · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Generation of a newRNA (New York, N.Y.) · 2023
    Article
  14. Article
  15. Review
  16. Review
  17. RNA Metabolism in T Lymphocytes.Immune network · 2022
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Taisuke NakahamaDepartment of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan nakahama@rna.med.osaka-u.ac.jp ykawahara@rna.med.osaka-u.ac.jp.
Yuki KatoDepartment of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Jung In KimDepartment of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Tuangtong VongpipatanaDepartment of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Yutaka SuzukiLaboratory of Systems Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.
Carl R WalkleySt Vincent's Institute and Department of Medicine, St. Vincent's Hospital, University of Melbourne, Fitzroy, Vic., Australia.ORCID 0000-0002-4784-9031
Yukio KawaharaDepartment of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan nakahama@rna.med.osaka-u.ac.jp ykawahara@rna.med.osaka-u.ac.jp.ORCID 0000-0002-2629-9405
The University of Osaka · JPSt Vincent's Hospital Melbourne · AUThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cells play a crucial role in the adaptive immune system, and their maturation process is tightly regulated. Adenosine deaminase acting on RNA 1 (ADAR1) is the enzyme responsible for adenosine-to-inosine RNA editing in dsRNAs, and loss of ADAR1 activates the innate immune sensing response via melanoma differentiation-associated protein 5 (MDA5), which interprets unedited dsRNA as non-self. Although ADAR1 is highly expressed in the thymus, its role in the adaptive immune system, especially in T cells, remains elusive. Here, we demonstrate that T cell-specific deletion of

Indexed as

AutoimmunityRNA EditingSelf ToleranceAdenosine DeaminaseAnimalsCD4-Positive T-LymphocytesCell DifferentiationColitisGene DeletionInflammationInterferon-Induced Helicase, IFIH1InterferonsLymphocyte ActivationMice, KnockoutReceptors, Antigen, T-CellSignal TransductionADAR1 protein, mouseAdenosine DeaminaseIfih1 protein, mouseInterferon-Induced Helicase, IFIH1InterferonsReceptors, Antigen, T-CellMDA5negative selectionRNA editingspontaneous colitisT cell maturation

Identifiers

PMID30361393
PMCPMC6280791
OpenAlexW2898487027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.