ArticleScience (New York, N.Y.)2018
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
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In one paragraph
Article in Science (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 648 papers, 1 of them a synthesis that pooled it.
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648citing papers in PubMed, 1 pooled it
33.1field-weighted citation impact, top 1% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
648 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,030 citations in OpenAlex.
- Research trends and topics on sepsis immunosuppression: a bibliometric and visual analysis of global research from 2004 to 2024.Frontiers in medicine · 2025Pooled it
- PARP inhibitors enhance antitumor immune responses by triggering pyroptosis via TNF-caspase 8-GSDMD/E axis in ovarian cancer.Journal for immunotherapy of cancer · 2024Trial
- Integrative multi-omics reveals CUL4B as a modulator of macrophage pyroptosis and innate defense againstScience advances · 2026Article
- The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Igniting antitumour immunity with cancer cell pyroptosis.Nature reviews. Cancer · 2026Review
- Macrophage-driven pathological ossification of the posterior longitudinal ligament: mechanistic insights and therapeutic opportunities.Bone research · 2026Review
- Human ZBP1 is a potent inducer of cell death through mechanisms divergent from mouse ZBP1.EMBO reports · 2026Article
- Gasdermin-Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer.Cancer science · 2026Review
- Theme and variations: activation and regulation of gasdermin-mediated inflammation.Biochemical Society transactions · 2026Review
- PANoptosis in the pathogenesis of myelodysplastic syndromes.Molecular oncology · 2026Review
- Review
- Pyroptosis: Molecular mechanisms and function.Journal of physiology and biochemistry · 2026Review
- Direct visualization of native GSDMD pores reveals lipid-driven stabilization during pyroptosis.Science advances · 2026Article
- Molecular switches in cell death: the interplay of apoptosis and pyroptosis in cancer.Cell communication and signaling : CCS · 2026Review
- Review
- Decoding PANoptosis: Crosstalk of cell death pathways in immunity and inflammation.Immunologic research · 2026Review
- The challenge of cell death switching in inflammasome-targeted therapies for bacterial and viral infections.Communications biology · 2026Review
- Regulated Cell Death in Idiopathic Pulmonary Fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Targeting non-apoptotic regulated cell death (RCD) to treat neurodegenerative diseases.Acta pharmaceutica Sinica. B · 2026Review
- Loss of DNA methyltransferase 3a enhances Caspase-8 transcription and promotes cardiomyocyte pyroptosis during myocardial infarction.Nature communications · 2026Article
588 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 3 countries.
Pontus OrningProgram in Innate Immunity, Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-6177-6916
Dan WengProgram in Innate Immunity, Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Kristian StarheimProgram in Innate Immunity, Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Dmitry RatnerProgram in Innate Immunity, Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-1706-2596
Zachary BestProgram in Innate Immunity, Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-8645-6441
Bettina LeeDepartment of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA.
Alexandria BrooksProgram in Innate Immunity, Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.ORCID 0000-0002-1119-2568
Shiyu XiaDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Hao WuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-7281-8579
Michelle A KelliherDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.ORCID 0000-0001-9211-3659
Scott B BergerPattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA.
Peter J GoughPattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA.ORCID 0000-0002-5110-9300
John BertinPattern Recognition Receptor Discovery Performance Unit, Immuno-inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426, USA.
Megan M ProulxDepartment of Microbiology and Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.ORCID 0000-0002-9524-8302
Jon D GoguenDepartment of Microbiology and Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Nobuhiko KayagakiDepartment of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA.
Katherine A FitzgeraldProgram in Innate Immunity, Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Egil LienProgram in Innate Immunity, Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA. egil.lien@umassmed.edu.ORCID 0000-0002-8536-2419
University of Massachusetts Chan Medical School · USGlaxoSmithKline (United States) · USBoston Children's Hospital · US
Funding
Rip Proteins in Innate Immune SignalingR01AI075118 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KELLIHER, MICHELLE ALICE · 2009 to 2024
$6.7MBiology of Infectious Diseases &InflammationT32AI007538 · NIAID · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Michelle A Ozbun · 1998 to 2026
$5.2MNLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress SensingR01AI124491 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WU, HAO · 2016 to 2025
$5.1MGene Regulation in Innate ImmunityR37AI067497 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A. · 2015 to 2024
$4.6MSMOCs: Novel Signal Transduction Complexes as New Targets for Drug DiscoveryDP1HD087988 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI WU, HAO · 2015 to 2019
$4.4MUMass Chan Medical School Summer Undergraduate Research ProgramR25HL092610 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BRIAN C LEWIS, Pranoti Mandrekar · 2008 to 2026
$2.6MElucidating the structural mechanism of pore formation by the (GSDM) Gasdermin familyR01AI139914 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WU, HAO · 2018 to 2022
$2.6MInnate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5MRole of PISA; a PYHIN Family Member in Intracellular DNA RecognitionR01AI083713 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A., LATZ, EICKE · 2009 to 2013
$2.0MRegulation of Type I Interferon Gene Expression in the Innate Immune ResponseR01AI067497 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A. · 2006 to 2010
$2.0MThe role of LPS-TLR4 signaling in live vaccine-induced protective responsesR01AI075318 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIEN, EGIL · 2009 to 2013
$1.9MBacterial inhibition of Pyrin inflammasome activationR21AI128547 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIEN, EGIL · 2017 to 2018
$461kNHLBI NIH HHS R25 HL092610NIAID NIH HHS F30 AI129237NIAID NIH HHS R01 AI067497NIAID NIH HHS R01 AI075118NIAID NIH HHS R01 AI075318NIAID NIH HHS R01 AI083713NIAID NIH HHS R01 AI124491NIAID NIH HHS R01 AI139914NIAID NIH HHS R21 AI128547NIAID NIH HHS R37 AI067497NIAID NIH HHS R56 AI067497NIAID NIH HHS R56 AI075118NIAID NIH HHS T32 AI007538NIAID NIH HHS T32 AI095213NICHD NIH HHS DP1 HD087988
Abstract
Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming fragment that controls pyroptosis in macrophages. GSDMD is processed via inflammasome-activated caspase-1 or -11. It is currently unknown whether macrophage GSDMD can be processed by other mechanisms. Here, we describe an additional pathway controlling GSDMD processing. The inhibition of TAK1 or IκB kinase (IKK) by the
Indexed as
Host-Pathogen InteractionsAnimalsApoptosis Regulatory ProteinsBacterial ProteinsCaspase 8Cell DeathGasderminsHumansI-kappa B KinaseInflammasomesIntracellular Signaling Peptides and ProteinsMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinApoptosis Regulatory ProteinsBacterial ProteinsCaspase 8GasderminsGsdmd protein, mouseI-kappa B KinaseInflammasomesIntracellular Signaling Peptides and ProteinsMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesNLR Family, Pyrin Domain-Containing 3 ProteinPhosphate-Binding ProteinsYopP protein, Yersinia
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