Evidence map›Paper›PMID 30361380›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

Galectin-3 Targeting in Thyroid Orthotopic Tumors Opens New Ways to Characterize Thyroid Cancer.

Francesco De Rose, Miriam Braeuer, Sten Braesch-Andersen, Angela M Otto, Katja Steiger, Sybille Reder, Sabine Mall, Stephan Nekolla, Markus Schwaiger, Wolfgang A Weber and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Francesco De RoseNuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Miriam BraeuerNuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Sten Braesch-AndersenMabtech AB Research Laboratory, Stockholm, Sweden.
Angela M OttoMunich School of Biomedical Engineering, Technische Universität München, Garching, Germany.
Katja SteigerInstitute of Pathology, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Sybille RederNuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Sabine MallIII, Medical Department, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Stephan NekollaNuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Markus SchwaigerNuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Wolfgang A WeberNuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Armando BartolazziPathology Research Laboratory, Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden; and.
Calogero D'AlessandriaNuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany calogero.dalessandria@tum.de.
Technical University of Munich · DEKlinikum rechts der Isar · DEKarolinska University Hospital · SEMabtech (Sweden) · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preoperative characterization of thyroid nodules is challenging since thyroid scintigraphy fails to distinguish between benign and malignant lesions. Galectin-3 (gal-3) is expressed in well-differentiated and in undifferentiated thyroid cancer types but not in normal thyrocytes and benign thyroid lesions. Herein, we aimed to validate gal-3 targeting as a specific method to detect non-radioiodine-avid thyroid cancer in thyroid orthotopic tumor models.

Indexed as

AnimalsCell Line, TumorCell ProliferationCell Transformation, NeoplasticFemaleGalectin 3Gene Expression Regulation, NeoplasticHumansImmunoconjugatesIodine RadioisotopesMicePositron Emission Tomography Computed TomographyRadioactive TracersSodium-Iodide SymportersSpheroids, CellularSymportersGalectin 3ImmunoconjugatesIodine-124Iodine RadioisotopesRadioactive TracersSodium-Iodide SymportersSymporters124Igalectin-3orthotopic modelsPET imagingthyroid tumor

Identifiers

PMID30361380
PMCPMC6581231
OpenAlexW2898171805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.