Trial reportHeart (British Cardiac Society)2019
Out-of-hospital initiation of hypothermia in ST-segment elevation myocardial infarction: a randomised trial.
Trial report in Heart (British Cardiac Society), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01777750 (Strategic Target Temperature Management in Myocardial Infarction), which is not on this map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Strategic Target Temperature Management in Myocardial Infarction
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Impact of Mild Hypothermia As Adjunctive Therapy in Patients With ST-Elevation Myocardial Infarction: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Pooled it
- Hypothermia in patients with acute myocardial infarction: a meta-analysis of randomized trials.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Pooled it
- Pooled it
- Kinetics of 2 different high-sensitive troponins during targeted temperature management in out-of-hospital cardiac arrest patients with acute myocardial infarction: a post hoc sub-study of a randomised clinical trial.BMC cardiovascular disorders · 2022Trial
- Exploratory echocardiographic strain parameters for the estimation of myocardial infarct size in ST-elevation myocardial infarction.Clinical cardiology · 2021Trial
- Therapeutic hypothermia in patients with acute myocardial infarction complicated by out-of-hospital cardiac arrest.BMC medicine · 2025Observational
- Malondialdehyde-specific natural IgM inhibit NETosis triggered by culprit site-derived extracellular vesicles from myocardial infarction patients.European heart journal · 2025Article
- SCAI Expert Consensus Statement on the Management of Patients With STEMI Referred for Primary PCI.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
- Hypothermia for Cardioprotection in Acute Coronary Syndrome Patients: From Bench to Bedside.Journal of clinical medicine · 2024Review
- Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning.Pharmacological reviews · 2023Review
- Therapeutic hypothermia for acute myocardial infarction: a narrative review of evidence from animal and clinical studies.Korean journal of anesthesiology · 2022Review
- Hypothermia for Cardioprotection in Patients with St-Elevation Myocardial Infarction: Do Not Give It the Cold Shoulder Yet!Journal of clinical medicine · 2022Review
- Energy-sparing by 2-methyl-2-thiazoline protects heart from ischaemia/reperfusion injury.ESC heart failure · 2022Article
- Hypothermia and its role in patients with ST-segment-elevation myocardial infarction and cardiac arrest.Frontiers in cardiovascular medicine · 2022Article
- Copeptin Levels Are Independent from Mild Therapeutic Hypothermia but Do Not Predict Infarct Size in Patients Presenting with ST-Segment Elevation Myocardial Infarction.Journal of cardiovascular development and disease · 2021Article
- Insight into the use of tympanic temperature during target temperature management in emergency and critical care: a scoping review.Journal of intensive care · 2021Article
- Sonothrombolysis in the ambulance for ST-elevation myocardial infarction: rationale and protocol.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2021Article
- Cardioprotective effect of combination therapy by mild hypothermia and local or remote ischemic preconditioning in isolated rat hearts.Scientific reports · 2021Article
- Mild Therapeutic Hypothermia Alters Hemostasis in ST Elevation Myocardial Infarction Patients.Frontiers in cardiovascular medicine · 2021Article
- Effects of Therapeutic Hypothermia on Normal and Ischemic Heart.Frontiers in cardiovascular medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of prereperfusion hypothermia initiated in the out-of-hospital setting in awake patients with ST-segment elevation myocardial infarction (STEMI) on myocardial salvage measured by cardiac MRI (CMR).
methodsHypothermia was initiated within 6 hours of symptom onset by the emergency medical service with surface cooling pads and cold saline, and continued in the cath lab with endovascular cooling (target temperature: ≤35°C at time of reperfusion). Myocardial salvage index (using CMR) was compared in a randomised, controlled, open-label, endpoint blinded trial to a not-cooled group of patients at day 4±2 after the event.
resultsAfter postrandomisation exclusion of 19 patients a total of 101 patients were included in the intention-to-treat analysis (control group: n=54; hypothermia group: n=47). Target temperature was reached in 38/47 patients (81%) in the intervention group. Study-related interventions resulted in a delay in time from first medical contact to reperfusion of 14 min (control group 89±24 min; hypothermia group 103±21 min; p<0.01). Myocardial salvage index was 0.37 (±0.26) in the control group and 0.43 (±0.27) in the hypothermia group (p=0.27). No differences in cardiac biomarkers or clinical outcomes were found. In a CMR follow-up 6 months after the initial event no significant differences were detected.
conclusionOut-of-hospital induced therapeutic hypothermia as an adjunct to primary percutaneous coronary intervention did not improve myocardial salvage in patients with STEMI. TRIAL REGISTRATION NUMBER: NCT01777750.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.