Evidence map›Paper›PMID 30360578›Full record

ArticleInternational journal of molecular sciences2018

HPV16-Related Cervical Cancers and Precancers Have Increased Levels of Host Cell DNA Methylation in Women Living with HIV.

Wieke W Kremer, Marjolein van Zummeren, Daniëlle A M Heideman, Birgit I Lissenberg-Witte, Peter J F Snijders, Renske D M Steenbergen, Greta Dreyer, Chris J L M Meijer

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
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  7. Article
  8. Article
  9. Characterization of cervical biopsies of women with HIV and HPV co-infection using p16Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Wieke W KremerDepartment of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands. w.kremer@vumc.nl.
Marjolein van ZummerenDepartment of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands. ma.vanzummeren@vumc.nl.
Daniëlle A M HeidemanDepartment of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands. dam.heideman@vumc.nl.
Birgit I Lissenberg-WitteDepartment of Epidemiology and Biostatistics, Amsterdam Public Health, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands. b.witte@vumc.nl.
Peter J F SnijdersDepartment of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Renske D M SteenbergenDepartment of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands. r.steenbergen@vumc.nl.ORCID 0000-0002-2327-9839
Greta DreyerDepartment of Obstetrics and Gynaecology, University of Pretoria, Pretoria 0002, South Africa. gretadreyer@mweb.co.za.
Chris J L M MeijerDepartment of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands. cjlm.meijer@vumc.nl.
Amsterdam University Medical Centers · NLUniversity of Pretoria · ZA

Funding

Vrije Universiteit Amsterdam University Research Fellowship
6 · The paper itself

Abstract

Data on human papillomavirus (HPV) type-specific cervical cancer risk in women living with human immunodeficiency virus (WLHIV) are needed to understand HPV⁻HIV interaction and to inform prevention programs for this population. We assessed high-risk HPV type-specific prevalence in cervical samples from 463 WLHIV from South Africa with different underlying, histologically confirmed stages of cervical disease. Secondly, we investigated DNA hypermethylation of host cell genes

Indexed as

AdolescentAdultBasic Helix-Loop-Helix ProteinsCervix UteriDNA MethylationFemaleHIV InfectionsHuman papillomavirus 16HumansLIM-Homeodomain ProteinsMiddle AgedTranscription FactorsUterine Cervical DysplasiaUterine Cervical NeoplasmsYoung AdultASCL1 protein, humanBasic Helix-Loop-Helix ProteinsLIM homeobox protein 8LIM-Homeodomain ProteinsTranscription FactorsDNA methylationhigh-grade cervical intraepithelial neoplasiahuman immunodeficiency virushuman papillomavirusuterine cervical neoplasms

Identifiers

PMID30360578
PMCPMC6274896
OpenAlexW2896379490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.